| Survivin蛋白和LMP1在鼻咽癌组织中的表达关系 |
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| 引用本文： | 刘强和,向秋,伍红良,何晓松,刘芳贤,雷迅. Survivin蛋白和LMP1在鼻咽癌组织中的表达关系[J]. 华夏医学, 2007, 20(2): 175-177 |
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| 作者姓名： | 刘强和 向秋 伍红良 何晓松 刘芳贤 雷迅 |
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| 作者单位： | 桂林医学院附属医院耳鼻咽喉-头颈外科,广西,桂林,541001;桂林医学院医药生物技术重点实验室,广西,桂林,541004 |
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| 基金项目： | 广西科学技术厅科研基金资助课题(桂科自0640187)，广西卫生厅科研基金资助课题(重2006522003-05) |
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| 摘 要： | 目的：探讨凋亡抑制基因Survivin蛋白和EB病毒潜伏膜蛋白（LMP1）在鼻咽癌组织中的表达情况以及它们之间的关系.方法：应用免疫组织化学技术S-P法对68例鼻咽癌组织标本进行凋亡抑制基因Survivin蛋白与EB-LMP1的表达检测.结果：鼻咽癌组织Survivin蛋白产物的阳性率为82.4%（56/68）,LMP1阳性率为67.6%（46/68）;56例Sur-vivin蛋白表达的阳性鼻咽癌标本中,有42例LMP1阳性,共同阳性率75.0%（42/56）,12例Survivin蛋白表达的阴性鼻咽癌标本中,9例LMP1阴性,共同阴性率66.7%（9/12）,两者之间高度相关（P〈0.01）.结论：鼻咽癌组织中凋亡抑制基因Survivin蛋白的表达与LMP1的表达密切相关.
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| 关 键 词： | Survivin蛋白 潜伏膜蛋白 鼻咽癌 |
| 文章编号： | 1008-2409(2007)02-0175-03 |
| 修稿时间： | 2006-09-14 |
Correlation expression of Survivin and LMP1 in nasopharyxgeal carcinoma |
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| LIU Qiang-he,XIANG Qiu,WU Hong-liang,et al.. Correlation expression of Survivin and LMP1 in nasopharyxgeal carcinoma[J]. Acta Medicinae Sinica, 2007, 20(2): 175-177 |
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| Authors: | LIU Qiang-he XIANG Qiu WU Hong-liang et al. |
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| Affiliation: | LIU Qiang-he,XIANG Qiu,WU Hong-liang,et al.The Affiliated Hospital of Guilin Medical College,Guilin 541001,China |
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| Abstract: | Objective: To study the relationship between the expression of apoptotic inhibitor gene Survivin protein and EBV latent membrane protein 1(LMP1) in nasopharyngeal carcinoma(NPC).Methods: The expression of Survivin and LMP1 in 68 cases of NPC was tested by immunocytochemical S-P staining.Results: Positive expression rate of Survivin was 82.4%(56/68),LMP1 was 67.6%(46/68),respectively.Survivin and LMP1 both positive expression rate were 75.0%(42/56),and that both negative expression rate was 66.7%(9/12),high significant recorrelation was observed in them(P<0.01).Conclusion: There is a close relationship existing between Survivin and LMP1 in NPC,which may play some role in genes and development of NPC. |
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| Keywords: | Survivin latent membrane protein 1 nasopharyngeal carcinoma |
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