| 冠状动脉结扎与腹主动脉缩窄所致慢性心力衰竭大鼠模型比较 |
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| 引用本文： | 莫新玲,谢福生,严冬雪,李全忠,李星虹.冠状动脉结扎与腹主动脉缩窄所致慢性心力衰竭大鼠模型比较[J].华夏医学,2009,22(1). |
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| 作者姓名： | 莫新玲 谢福生 严冬雪 李全忠 李星虹 |
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| 作者单位： | 桂林医学院附属医院,广西,桂林,541001 |
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| 摘 要： | 目的:比较冠状动脉结扎术与腹主动脉缩窄术所建立的大鼠慢性心力衰竭 (CHF)模型在病理及病理生理学等方面的差别.方法:实验大鼠随机分为4组:正常对照组 (假冠状动脉结扎术组S-LCL、假腹主动脉缩窄术组S-AAC)、冠状动脉结扎术组 (LCL组)和腹主动脉缩窄术组(AAC组),8周后测定血流动力学变化,计算左心室重量/体重比值(LVW/BW)观察心肌组织形态学改变.结果:LVW/BW在LCL组、AAC组均增加.两种CHF模型左室压力上升和下降最大速率(±dp/dt max)均较正常对照组降低(P<0.01).左室收缩压(LVSP)、左室舒张末压(LVEDP)均较正常对照组升高,而且AAC组比LCL组升高更明显.光镜下LCL 组梗死区纤维组织替代坏死心肌细胞,大量炎性细胞浸润,非梗死区心肌细胞肥大伴间质显著增生;AAC 组心肌细胞肥大,排列紊乱,小血管壁增厚,间质增生伴少量炎细胞浸润.结论:冠脉结扎术和腹主动脉缩窄术均是建立慢性心力衰竭大鼠模型的有效方法.两者的差别是:腹主动脉缩窄术建立的是压力超负荷型CHF模型,冠脉结扎术建立的是低心输出量型CHF模型.
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| 关 键 词： | 动物模型 大鼠 冠状动脉结扎 腹主动脉缩窄 心力衰竭 |
Comparison between experimental models of chronic heart failure established by coronary artery ligature and abdominal aorta constriction |
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| MO Xin-ling,XIE Fu-sheng,YAN Dong-xue,et al..Comparison between experimental models of chronic heart failure established by coronary artery ligature and abdominal aorta constriction[J].Acta Medicinae Sinica,2009,22(1). |
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| Authors: | MO Xin-ling XIE Fu-sheng YAN Dong-xue |
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| Institution: | MO Xin-ling,XIE Fu-sheng,YAN Dong-xue,et al.Cardiovascular Department,The Affiliated Hospital of Guilin Medical College,Guilin 541001,China |
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| Abstract: | Objective:To compare the pathologic and pathophysiologic characteristics of two experimental models of chronic heart failure(CHF) established by coronary artery ligature and abdominal aorta constriction separately.Methods:Wistar rats were randomly divided into four groups : AAC,S-AAC,LCL and S-LCL groups.Coronary artery ligature and abdominal aorta constriction were induced respectively in group LCL and AAC to establish models of CHF.The changes in hemodynamic parameters,left ventricular weight/body weight(... |
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| Keywords: | model rats coronary artery ligature abdominal aorta constriction heart failure |
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