C-erbB-2、P53、ER和PR在乳腺癌中的表达及意义

目的:探讨C-erbB-2、P 53、ER和PR蛋白在乳腺癌中的表达及其临床意义。方法:采用免疫组化SP方法,检测54例乳腺癌组织及其癌旁正常乳腺组织中C-erbB-2、P 53、ER和PR蛋白的表达情况。结果:在54例乳腺癌中C-erbB-2、P 53、ER和PR蛋白阳性表达率分别为87.0%(47/54)、83.3%(45/54)、66.7%(36/54)和61.1%(33/54);C-erbB-2和P 53阳性表达率与临床分期、有无淋巴结转移有关(P<0.05);C-erbB-2、P 53、ER和PR阳性表达率与肿瘤大小无关(P>0.05)。C-erbB-2和P 53共同阳性表达与淋巴结转移有关(P<0.01)。结论:联合检测乳腺癌C-erbB-2、P 53、ER和PR基因蛋白对判断预后和指导内分泌治疗有实用价值。

Expression and significance of C-erbB-2, P53, ER and PR in breast carcinoma

Objective: To study the expression of C-erbB-2,P53,ER and PR and discuss their relationship and clinical significance in breast carcinoma.Methods: The expression of C-erbB-2,P53,ER and PR protein were detected in 54 cases of breast carcinoma with immunohistochemical S-P technique.Results: in 54 cases of breast carcinoma the positive rates of C-erbB-2:87.0%(47/54),P53:83.3%(45/54),ER:66.7%(36/54) and PR:61.1%(33/54),respectively.There existed correlation between the positive expressions of C-erbB-2 and P53 with clinical stages and lymphatic metastasis(P<0.05).There was no correlation between the positive expressions of C-erbB-2,P53,ER and PR with the measurements of the tumor(P>0.05).Conclusion: Gene expressions of C-erbB-2,P53,ER and PR possess the practical value in determining prognosis and endocrinotherapy.