| 羧甲基壳聚糖的制备及抑菌作用的研究 |
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| 引用本文： | 葛为公,杨红梅,黄崇基,何敏,曾立威.羧甲基壳聚糖的制备及抑菌作用的研究[J].华夏医学,2005,18(6):903-904. |
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| 作者姓名： | 葛为公 杨红梅 黄崇基 何敏 曾立威 |
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| 作者单位： | 桂林医学院,广西,桂林,541004;桂林南药集团公司,广西,桂林,541002;南宁食品药品监督管理局,广西,南宁,530021 |
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| 基金项目： | 广西自然科学基金资助项目(桂科青0229035) |
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| 摘 要： | 目的：研究羧甲基壳聚糖的合成反应及其抑菌活性.方法：用化学方法修饰壳聚糖,用稀释法对常见病原菌进行抑菌实验.结果：产物经红外光谱证实,壳聚糖已被氯乙酸所修饰,产物对金黄色葡萄球菌、大肠杆菌、绿脓杆菌均有抑菌作用.结论：本法制得的羧甲基壳聚糖具有优越的水溶性能,对常见致病菌有一定的抑菌活性.
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| 关 键 词： | 壳聚糖 羧甲基壳聚糖 抑菌活性 |
| 文章编号： | 1008-2409(2005)06-0903-02 |
| 修稿时间： | 2005年5月24日 |
Preparation of carboxymethyl chitosan and its bacteriostasis |
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| GE Wei-gong,YANGHong-mei,HUANG Chong-ji,et al..Preparation of carboxymethyl chitosan and its bacteriostasis[J].Acta Medicinae Sinica,2005,18(6):903-904. |
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| Authors: | GE Wei-gong YANGHong-mei HUANG Chong-ji |
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| Institution: | GE Wei-gong,YANGHong-mei,HUANG Chong-ji,et al.Guilin Medical College,Guilin 541004,China |
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| Abstract: | Objective:To develop a synthesis method of the carboxymethyl chitosan(CM-CTS) and to study its bacteriostatic effect.Methods: Purified chitosan was modified by way of chemistry,using methods of dilution to study the bacteriostasis to some ordinary bacteria.Results: The infra-red spectragram of the product showed the chitosan had been modified by chloroacetic acid.S.aureus,E.coli,and P.aeruginosa could be inhibited to different degrees by CM-CTS.Conclusion: The product has superior water-soluble property.It also has antibacterial action to ordinary bacteria. |
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| Keywords: | chitosan carboxymethyl chitosan antimicrobial ability |
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