补肾止颤方加减治疗肝肾不足型帕金森病的随机对照研究

目的:观察补肾止颤方加减治疗肝肾不足型帕金森病(PD)的临床疗效。方法:纳入肝肾不足型PD患者80例,采用随机数字表分为治疗组和对照组,每组40例。对照组患者给予常规西药治疗,治疗组患者给予常规西药结合补肾止颤方加减口服治疗,治疗周期为12周,治疗结束后随访12周。治疗前及治疗12周、24周后,评价并比较两组患者的统一PD评定量表(UPDRS)、非运动症状量表(NMSS)、PD患者生活质量问卷(PDQ-39)、疲劳严重度量表(FSS)评分及中医证候积分。结果:治疗过程中,治疗组7例患者脱落或剔除,对照组8例患者脱落或剔除,最终治疗组33例、对照组32例纳入统计分析。治疗12周、24周后,治疗组患者的UPDRS评分较治疗前有所下降,而对照组有所上升,但差异均无统计学意义(P>0.05);治疗24周后,治疗组患者的UPDRS评分明显低于对照组(P<0.05)。治疗后,治疗组患者的NMSS、PDQ-39、FSS评分及中医证候积分较治疗前均明显降低(P<0.05,P<0.01),且治疗组患者的NMSS、PDQ-39、FSS评分及中医证候积分均显著低于对照组(P<0.05,P<0.01)。结论:补肾止颤方加减可有效改善肝肾不足型PD患者的非运动症状和生活质量,缓解患者运动症状的进展,值得在临床中推广应用。

Modified Bushen Zhichan Decoction in the treatment of Parkinson’s disease with syndrome of deficiency of liver and kidney:A randomized controlled study

Objective: To observe the clinical efficacy of Modified Bushen Zhichan Decoction in the treatment of Parkinson’s disease(PD) with syndrome of deficiency of liver and kidney. Methods: Eighty PD patients with syndrome of deficiency of liver and kidney were included and randomly divided into the treatment group and control group according to random number table, 40 cases in each group. The patients in the control group were treated with conventional western medicine and the patients in the treatment group were orally treated with conventional western medicine combined with Modified Bushen Zhichan Decoction, with a treatment course of 12 weeks and follow-up for 12 weeks after treatment. Before treatment and after treatment for 12 weeks and 24 weeks, the scores of unified Parkinson’s disease rating scale(UPDRS), non-motor symptom scale(NMSS), Parkinson’s disease questionnaire on quality of life(PDQ-39) and fatigue severity scale(FSS) and the Chinese medical syndrome score were evaluated and compared. Results: In the course of treatment, 7 patients in the treatment group and 8 patients in the control group shed or were excluded. Finally, 33 cases in the treatment group and 32 cases in the control group were included in the statistical analysis. After treatment for 12 weeks and 24 weeks, the UPDRS scores of the treatment group showed a downward trend and the UPDRS scores of the control group showed an upward trend compared with those before treatment, but with no statistically significant differences(P>0.05). After treatment for 24 weeks, the UPDRS score of the treatment group was significantly lower than that of the control group( P<0.05). After treatment,the scores of NMSS,PDQ-39,FSS and Chinese medical syndrome in the treatment group were significantly decreased compared with those before treatment( P<0.05,P<0.01),and the scores of NMSS,PDQ-39,FSS and Chinese medical syndrome in the treatment group were significantly lower than those in the control group( P<0.05,P<0.01). Conclusion: Modified Bushen Zhichan Decoction can effectively improve the non-motor symptoms and life quality of PD patients with syndrome of deficiency of liver and kidney,and alleviate the development of motor symptoms,which is worthy of clinical promotion and application.