| 清胆胶囊与养肝利胆颗粒对豚鼠胆色素结石炎症反应环节的影响 |
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| 引用本文： | 张静喆,梁晓强,章学林,顾宏刚,朱培庭.清胆胶囊与养肝利胆颗粒对豚鼠胆色素结石炎症反应环节的影响[J].上海中医药大学学报,2009(5):51-54. |
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| 作者姓名： | 张静喆 梁晓强 章学林 顾宏刚 朱培庭 |
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| 作者单位： | 上海中医药大学附属龙华医院普外科;上海市中医药研究院中医外科研究所; |
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| 基金项目： | 上海市重点学科建设基金资助项目(T0304);;上海市医学领军人才资助项目(LJ06048);;上海市教委科研创新基金资助项目(09YZ131) |
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| 摘 要： | 目的：观察两种不同治则的中药清胆胶囊和养肝利胆颗粒对豚鼠胆色素结石形成过程中炎症环节的影响。方法：应用雄性豚鼠建立胆色素结石模型，分别观察清胆胶囊和养肝利胆颗粒对该模型成石率、胆囊容积、胆汁中黏蛋白浓度及C反应蛋白（CRP）浓度等指标的影响。结果：清胆胶囊组与养肝利胆颗粒组成石率均显著降低（P〈0．01），胆囊容积明显减小（P〈0．05）；胆汁中黏蛋白及CRP浓度明显降低（P〈0．05），两种中药制剂对黏蛋白及CRP的影响无统计学意义。结论：清胆胶囊与养肝利胆颗粒对胆色素结石有良好的防治作用，而且二者在干预胆色素结石病炎症反应环节上的作用效果和机制基本相似。
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| 关 键 词： | 清胆胶囊 养肝利胆颗粒 胆色素结石 动物实验 |
Effects of "Qingdan Capsule" and "Yanggan Lidan Granule" on Inflammatory Reaction in Guinea Pigs with Pigmented Gallstones |
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| ZHANG Jing-zhe LIANG Xiao-qiang ZHANG Xue-lin GU Hong-gang ZHU Pei-ting.Effects of "Qingdan Capsule" and "Yanggan Lidan Granule" on Inflammatory Reaction in Guinea Pigs with Pigmented Gallstones[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2009(5):51-54. |
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| Authors: | ZHANG Jing-zhe LIANG Xiao-qiang ZHANG Xue-lin GU Hong-gang ZHU Pei-ting |
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| Institution: | ZHANG Jing-zhe1 LIANG Xiao-qiang2 ZHANG Xue-lin1 GU Hong-gang1 ZHU Pei-ting11.Department of Surgery,Longhua Hospital,Shanghai University of Traditional Chinese Medicine2.TCM Surgery Institute,Shanghai Academy of Traditional Chinese Medicine |
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| Abstract: | Objective:To study the effects of "QingDan Capsule"(QDJN) and "Yanggan Lidan Granule"(YGLD) which follow different therapeutic principles on inflammatory reaction in guinea pigs with pigmented gallstones.Methods:Animal model of pigmented gallstones was reproduced in male guinea pigs by hypodermic injection of lincomycin.Then the stone formation rate,gallbladder volume,mucin and C-reactive protein in bile were measured respectively.Results:Compared with model group,the rates of stone formation,gallbladder vo... |
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| Keywords: | "Qingdan Capsule" "Yanggan Lidan Granule" pigmented gallstone animal experiment |
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