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黄芪桂枝五物汤治疗脾肾阳虚型IgA肾病的临床研究
引用本文:侯卫国,高建东,关新,唐英.黄芪桂枝五物汤治疗脾肾阳虚型IgA肾病的临床研究[J].上海中医药大学学报,2008,23(3):38-41.
作者姓名:侯卫国  高建东  关新  唐英
作者单位:上海中医药大学附属曙光医院肾病科,上海中医药大学肾病研究所,上海,200021
摘    要:目的:观察黄芪桂枝五物汤对IgA肾病脾肾阳(气)虚证的疗效。方法:对IgA肾病属脾肾阳(气)虚证患者60例采用随机对照按2:1的比例,分为治疗组(黄芪桂枝五物汤)40例和对照组(西药潘生丁)20例,疗程均为2个月。结果:治疗组总有效率为72.5%,对照组为50.0%(P〈0.05),治疗组能有效缓解患者疲倦乏力,腰背酸痛,面肢浮肿,肢冷畏寒等症状,疗效明显优于对照组(P〈0.05~0.OD;治疗组对降低蛋白尿具有明显疗效(P〈0.05)。组间比较在降低尿红细胞,改善BUN、Scr方面无明显差异(P〉0.05),两组用药后均未发生不良反应。结论:黄芪桂枝五物汤对降低IgA肾病脾肾阳(气)虚证患者蛋白尿及血尿均有效,对改善临床疲倦乏力,腰背酸痛,面肢浮肿,畏寒肢冷等症状有明显疗效。

关 键 词:IgA肾病  脾肾阳虚证  潘生丁  黄芪桂枝五物汤  中医药疗法

Clinical Observation of "Huangqi Guizhi Wuwu Decoction" in Treatment of IgA nephropathy (IgAN) of Spleen-Kidney Yang (Qi) Deficiency Pattern
HOU Wei-guo,GAO Jian-dong,GUAN Xin,TANG Ying.Clinical Observation of "Huangqi Guizhi Wuwu Decoction" in Treatment of IgA nephropathy (IgAN) of Spleen-Kidney Yang (Qi) Deficiency Pattern[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2008,23(3):38-41.
Authors:HOU Wei-guo  GAO Jian-dong  GUAN Xin  TANG Ying
Institution:( Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Nephrology Institute, Shanghai University of Traditional Chinese Medicine)
Abstract:Objective: To observe the clinical efficacy of "Huangqi Guizhi Wuwu Decoction" in the treatment of IgA nephropathy (IgAN) of spleen-kidney yang(qi) deficiency pattern. Method: Sixty subjects were randomized into two groups with ratio of two to one: treatment group in which 40 cases were treated with "Huangqi Guizhi Wuwu Decoction", and control group in which 20 cases were treated with dipyridamole, with a course of two months. Results: The total effective rate of treatment group was 72-52%, much higher than 50% of control group(P〈 0.05). The remission of clinical symptoms including fatigue, back pain, face and llmb edema and aversion to cold was more significant in treatment group than that of control group (P〈 0.05-0.01).Besides, in the treatment group, the proteinuria was ameliorated significantly (P〈 0.05).There are no signitlcant differences in reducing urine erythrocyte, BUN and Scr between the two groups. Both of the two groups presented no adverse reactions. Conclusion: "Huangqi Guizhi Wuwu Decoction" can ameliorate the proteinuria and the urine erythrocyte of IgAN patients of spleen-kidney yang (qi) deficiency pattern, and relieve the patlents'clinical symptoms such as fatigue, back pain, face and limb edema and aversion to A cold significantly.
Keywords:IgA nephropathy (IgAN)  spleen-kidney yang(qi) deficiency pattern  TCM therapy  "Huangqi GuizhiWuwu Decoction"  dipyridamole
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