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细胞色素P450Ⅱ E1-基因多态性在酒精性肝病发病中的意义
引用本文:孟祥伟,迟宝荣,高沿航,孙逊.细胞色素P450Ⅱ E1-基因多态性在酒精性肝病发病中的意义[J].吉林大学学报(医学版),2003,29(4):451-453.
作者姓名:孟祥伟  迟宝荣  高沿航  孙逊
作者单位:1. 吉林大学第一医院消化内科,吉林,长春,130021
2. 吉林大学第一医院病理科
基金项目:日本文部省学术振兴会资助项目;;
摘    要:目的 :探讨细胞色素 P45 0 E1的基因型与酒精性肝病的相关性。方法 :采用 PCR- RFLP分析方法对 1 0 0例酒精性肝病患者 ,1 5 0例非酒精性肝病患者 ,2 5例酗酒无肝病者和 5 0例正常对照者进行 CYP45 0 E1多态性分析。结果 :CYP45 0 El分成 A型为 C1基因野生纯和子 ,B型为( C1 /C2 )基因的杂合子 ,C型为 C2基因的突变型纯合子。酒精性肝病中 A、B、C型分别 3%、93%、4%;酗酒无肝病组 A型为 1 0 0 %;非酒精性肝病中 A、B型分别 74%、2 6%;健康志愿者 A、B型分别 72 %、2 8%。酒精性肝病与酗酒无肝病组、非酒精性肝病及健康志愿者比较 ,有统计学意义。乙肝引起肝癌与酒精相关性肝癌的 A型明显减少 ,而 B型则明显增多 ,有统计学意义。结论 :C2基因与酒精性肝病的发病及与酒精性肝癌的发生有一定的相关性

关 键 词:肝疾病  酒精性  细胞色素P-450/遗传学  基因多态性
文章编号:1671-587X(2003)04-0451-03
修稿时间:2002年8月25日

The Significance of Cytochrome P450ⅡE1 Genetic Polymorphism of Pathogenesis in Alcoholic Liver Disease
MENG Xiang wei ,CHI Bao rong ,GAO Yan hang ,SUN Xun.The Significance of Cytochrome P450ⅡE1 Genetic Polymorphism of Pathogenesis in Alcoholic Liver Disease[J].Journal of Jilin University: Med Ed,2003,29(4):451-453.
Authors:MENG Xiang wei  CHI Bao rong  GAO Yan hang  SUN Xun
Institution:MENG Xiang wei 1,CHI Bao rong 1,GAO Yan hang 1,SUN Xun 2
Abstract:Objective: To explore the relationship between genotype of cytochrome P450ⅡE1 and alcoholic liver disease. Methods:PCR RFLP method was used. Results:According to CYP450 Ⅱ E1 gene, type A was the hemozygote of wild type in gene C1,type B was the heterozygote of gene (C1/C2) and type C was the mutational hemozygote of gene C2 .Type A, B and C in the group of alcoholic liver disease were 3%, 93% and 4%, respectively. The rate of type A in the group of drinking without liver disease was 100%. Type A and B in the group of non alcoholic liver disease were 74% and 26%. And that in normal control groups were 72% and 28%. Comparing alcoholic liver disease group with drinking without liver disease group and comparing the patients with non alcoholic liver disease with the normal control group, the results were siginificant in statistics. Comparing liver carcinoma resulting from hepatitis B with alcohol, type A was more lower and B was more higher obviously. Conclusion: Gene C2 plays a role in the association between pathogenesis of alcoholic liver disease and occurrence of alcoholic liver carcinoma.
Keywords:Liver diseases  alcoholic  Cytochrome P  450/genetics  Genetic polymorphism
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