| 人参皂甙对老龄化大鼠心房肽基因表达的影响 |
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| 引用本文： | 刘剑剀,洪敏,李小林.人参皂甙对老龄化大鼠心房肽基因表达的影响[J].吉林大学学报(医学版),1992(2). |
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| 作者姓名： | 刘剑剀 洪敏 李小林 |
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| 作者单位： | 白求恩医科大学基础医学院生物化学教研室
(刘剑剀，洪敏)，白求恩医科大学基础医学院生物化学教研室(李小林) |
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| 摘 要： | 给24～26月龄的雄性和雌性大鼠,腹腔注射人参茎叶总甙水溶液,50mg/kg体重,每日1次,连续7次。用冷酚法提取心房总RNA,与α-~(32)P标记的大鼠心房肽前体原cDNA(r—prepro—ANP—cDNA)探针杂交。结果表明,人参皂甙对老龄化大鼠心房肽基因表达的作用是受性别影响的。
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| 关 键 词： | 心房肽 人参皂甙 分子杂交 老龄化 基因表达 |
EFFECT OF GINSENOSIDES ON ATRIAL NATRIURETIC PEPTEDE GENE EXPRESSION IN AGED RATS |
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| Liu Jiankai,Hong Min,Li Xiaolin.EFFECT OF GINSENOSIDES ON ATRIAL NATRIURETIC PEPTEDE GENE EXPRESSION IN AGED RATS[J].Journal of Jilin University: Med Ed,1992(2). |
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| Authors: | Liu Jiankai Hong Min Li Xiaolin |
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| Institution: | Department of Biochemistry |
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| Abstract: | The effect of ginsenosides on atrial natriuretic peptide was studied in aged rats. In both male and female rats at the age of 24 - 26 months (380 - 600g), aqueous solution of Ginsenosides prepared from Ginseng stems and leaves was given at a dose of 50mg/kg body weight per day i. p. for 7 days. Then the total atria RNA was extracted with cold phenol method and hybridized to a-32P labeled r-prepro-ANP-cDNA probe. Our results suggest that the effects of Ginsenosides on atrial natriuretic peptide gene expression in aging rats were sexually regulated. |
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| Keywords: | Atrial natriuretic peptide Gene expression Molecular hybridization Aging |
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