西洋参叶三醇组皂苷对乳腺癌放疗患者外周血免疫球蛋白、补体水平及淋巴细胞CD4、CD8和CD25表达的影响

目的：探讨西洋参叶三醇组皂苷（PQL）对乳腺癌放疗患者细胞免疫功能的影响。方法：30 例乳腺癌放疗患者随机分为PQL观察组（17例）和对照组（13例）；两组在进行放射治疗的同时，PQL观察组口服PQL，对照组不给该药；放疗40 Gy后取外周血测定白细胞计数，免疫球蛋白IgG、IgA、IgM及补体C3、C4、T淋巴细胞转化率和淋巴细胞CD4、CD8、CD25阳性细胞百分率。 结果：在对照组中，患者的外周血白细胞计数为(4.02±0.67)×10⁹•L^-1，淋巴细胞转化率为7 966±1 562，而PQL实验组中分别为(6.17±1.20)×10⁹•L^-1，18 035±1 577，明显高于对照组（P<0.001)。在PQL观察组中，CD8及CD25阳性细胞的百分率(%)分别为20.9±5.08和41.3±6.15，与对照组比较差异具有显著性（P<0.05，P<0.001)。两试验组中免疫球蛋白IgG、IgA、IgM及补体C3、C4水平差异无显著性。结论：PQL增强乳腺癌放疗患者的细胞免疫功能。

Effects of PQL on levels of immunal proteins, C3, C4 and expressions of CD4, CD8, and CD25 on lymphocytes of peripherial blood in patients with breast carcinoma undergoing radiotherapy

Objective To evaluate the effects of panaxatriol in quinquefolium leaf (PQL) on immune functions in the patients with breast carcinoma undergoing radiotherapy. Methods Thirty patients with breast carcinoma undergoing radiotherapy were randomly divided into 2 groups: panaxatriol treatment group (n=17) and control group (n=13). All patients in panaxatriol treatment group were administrated with PQL as well as radiotherapy, no administration in control group. After radiotherapy with 40 Gy, the white cells count and IgG, IgA, IgM, C3, and C4 values, and the percentages of CD4~+, CD8~+, CD25~+ and lymphocyte transformation rate of peripheral blood in the patients were examined. Results There were (4.02±0.67)×10~9·L~ -1 and (6.17±1.20)×10~9·L~ -1 white blood cells,respectively, in control and PQL groups. The lymphocyte transformation rate of peripheral blood were 7 966±1 562 in the control group, while 18 035±1 577 in PQL group, which was significantly higher than that in control group(P<0.001). The percentages of CD8~+ and CD25~+ T lymphocytes in PQL group were significantly higher than those in control group (P<0.05, P<0.001). Conclusion The PQL could enhance the cellular immune function in patients with breast carcinoma undergoing radiotherapy.