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准分子激光屈光性角膜切削术中应用丝裂霉素C预防角膜上皮下雾状混浊形成的meta分析
引用本文:吴荒,王春勇,王宜,宋跃,郑雅娟.准分子激光屈光性角膜切削术中应用丝裂霉素C预防角膜上皮下雾状混浊形成的meta分析[J].吉林大学学报(医学版),2006,32(4):683-686.
作者姓名:吴荒  王春勇  王宜  宋跃  郑雅娟
作者单位:1. 吉林大学第二医院眼科,吉林 长春 130041;2. 吉林大学公共卫生学院流行病学教研室,吉林 长春 130021
基金项目:国家自然科学基金 , 吉林省长春市科技局科研项目
摘    要:目的:探讨在准分子激光屈光性角膜切削术(PRK)中应用丝裂霉素C对抑制角膜上皮下雾状混浊(haze)形成的效果。 方法:检索Medline、OVID医学期刊全文数据库、中国学术期刊全文库、万方数据资源系统收录的1995年4月-2005年4月10年发表的关于丝裂霉素C与PRK相关的对照研究,并辅以手工检索。 结果:共纳入2项随机对照试验,异质性Q检验无统计学差异(χ2=0.17, df=1, P=0.68)。 2项研究的OR值分别为0.17[95% CI 0.05~0.53]、0.10[95% CI 0.01~0.85];合并OR值为0.14[95% CI 0.05~0.40],与对照组比较差异有显著性(Z=3.75,P=0.000 2)。 结论:PRK术中局部应用0.02%丝裂霉素C可以明显减少高度近视眼术后的haze形成。

关 键 词:治疗作用  角膜切除术  光折射  准分子激光  方法  角膜上皮下雾状混浊  综合分析    
文章编号:1671-587X(2006)04-0683-04
收稿时间:2005-08-23
修稿时间:2005年8月23日

Meta-analysis of prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy
WU Huang,WANG Chun-yong,WANG Yi,SONG Yue,ZHENG Ya-juan.Meta-analysis of prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy[J].Journal of Jilin University: Med Ed,2006,32(4):683-686.
Authors:WU Huang  WANG Chun-yong  WANG Yi  SONG Yue  ZHENG Ya-juan
Institution:1. Department of Ophthalmology, Second Hospital,Jilin University, Changchun 130041,China;2. Department of Epidemiology,School of Public Health,Jilin University, Changchun 130021, China
Abstract:Objective To evaluate the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy(PRK).Methods Both a computer-aided search of Medline,OVID,CNKI,Wanfang data and an intensive search by hand were conducted to identify all randomized controlled trials assessing the effect of intraoperative using mitomycinC during PRK.Results Two studies were finally included.The Q test of homogeneity showed no difference between them(χ~2=0.17,df=1,P=0.68).The OR value of the studies were 0.1795% CI 0.05-0.53] and 0.1095% CI 0.01-0.85],respectively;the pooled OR was 0.14 95% CI 0.05-0.40],significant difference was found between experimental group and control group(Z=3.75,P=0.000 2).Conclusion Topical intraoperative application of 0.02% mitomycin-C can reduce haze formation in patients with highly near-sightedness after PRK.
Keywords:mitomycin/therapeutic use  keratectomy  photorefractive  excimer laser/methods  haze  meta-analysis  
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