秘灵王对Swiss鼠与裸鼠免疫功能的影响

采用秘灵王（ＭＬＷ）灌喂正常Ｓｗｉｓｓ鼠与先天性免疫缺陷裸鼠，观察ＭＬＷ对两品系小鼠免疫功能的影响，探讨ＭＬＷ的免疫调节效应。结果表明，ＭＬＷ可显著促进Ｓｗｉｓｓ鼠Ｔ、Ｂ细胞对丝裂原的反应性；促进胸腺细胞与骨髓细胞的自发增殖；促进脾细胞产生ＩＬ－１、ＩＬ－６的能力（Ｐ＜０．０１）。ＭＬＷ对裸鼠仅可促进Ｂ细胞对ＧＰＳ的反应性（Ｐ＜０．０５）。裸鼠与Ｓｗｉｓｓ鼠比较，裸鼠Ｂ细胞对ＬＰＳ、ＧＰＳ的反应性、骨髓细胞自发增殖、血清ＣＩＣ水平等指标均高于Ｓｗｉｓｓ鼠（０．０１＜Ｐ＜０．０５），而胸腺细胞自发增殖、血清溶菌酶含量、脾ＭΦ精氨酸酶水平均低于Ｓｗｉｓｓ鼠（Ｐ＜０．０５）。提示ＭＬＷ对正常鼠及免疫缺陷鼠有不同的免疫调节效应。

Effect of Milingwang on immunofunctions of Swiss mice and naked mice

The immunofunctions of Swiss mice and nude mice administered with effective dose of Milingwang (MLW) agent in stomach were observed.The results showed that MLW could evidently promote the reactivity of T lymphocytes and B lymphocytes of Swiss mice to mitogens,sponteneous proliferation of thymus and bone marrow cells,and ability of producting interleukin-1 and interleukin-6 of splenocytes (P<001).MLW could only increase the reactivity of B lymphocytes of nude mice to glycyrrhiza uralensis fisch polysaccharide (GPS) (P<005).Compared to thoes of Swiss mice,nude mice′s parameters of reativity of B lymphocytes to lipopolysaccharide (LPS) and GPS,sponteneous proliferation of bone marrow cells and sera circle immune complex (CIC) level were higher (P<005).However, the parameters of sponteneous proliferation of thymocytes,sera lysozyme level,level of arginase in macrophages of spleen were lower (P<005).It may be suggested that MLW has different immune regulation effect on normal Swiss mice and immunodeficiency mice.