| 单宁酸对糖尿病大鼠肾组织炎症因子表达的抑制作用 |
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| 引用本文： | 魏海峰,魏雁虹,李蕴潜,苗春生,李才.单宁酸对糖尿病大鼠肾组织炎症因子表达的抑制作用[J].吉林大学学报(医学版),2011,37(3):393-397. |
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| 作者姓名： | 魏海峰 魏雁虹 李蕴潜 苗春生 李才 |
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| 作者单位： | 吉林大学药学院实验药理与毒理学教研室,吉林,长春,130021;长春中医药大学附属医院病理科,吉林长春,130021;吉林省人民医院检验科,吉林,长春,130021;吉林大学第一医院神经外科,吉林,长春,130021;吉林大学药学院实验药理与毒理学教研室,吉林,长春,130021 |
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| 基金项目： | 国家自然科学基金资助课题(30800423) |
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| 摘 要： | 目的:观察单宁酸(TA)对链脲佐菌素(STZ)诱发糖尿病(DM)大鼠肾脏组织炎症因子表达的抑制作用,探讨其作用机制.方法:70只雄性Wistar大鼠随机分为对照组、DM组、氨基胍(AG)组、TA低剂量组和TA高剂量组.处理10周后检测各组大鼠肾脏功能指标血清肌酐(Cre)、尿素氮(BUN)及24 h尿蛋白排泄量],P...
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| 关 键 词： | 单宁酸 糖尿病肾病 细胞间黏附分子1 肿瘤坏死因子α |
| 收稿时间： | 2010-11-03 |
Inhibitory effects of tannic acid on inflammatory factor expressions of renal tissues in diabetic rats |
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| WEI Hai-feng,WEI Yan-hong,LI Yun-qian,MIAO Chun-sheng,LI Cai.Inhibitory effects of tannic acid on inflammatory factor expressions of renal tissues in diabetic rats[J].Journal of Jilin University: Med Ed,2011,37(3):393-397. |
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| Authors: | WEI Hai-feng WEI Yan-hong LI Yun-qian MIAO Chun-sheng LI Cai |
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| Institution: | （1. Department of Experimental Pharmacology and Toxicology,School of Pharmacy,Jilin University,Changchun 130021,China;2. Department of Pathology,Affiliated Hospital, Changchun University of Chinese Medicine,Changchun 130021,China;3. Department of Laboratory,People’s Hospital of Jilin Province,Changchun 130021,China;4. Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China） |
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| Abstract: | Objective To investigate the inhibitory effects of tannic acid(TA) on the expressions of renal inflammatory factors in streptozotocin(STZ)-induced diabetic rats and explore their mechanisms.Methods Seventy male Wistar rats were randomly divided into control group,diabetic model group(DM),aminoguanidine(AG) group,low dose TA group(TA20) and high dose TA group(TA30).After the rats were treated for 10 weeks,24 h urinary protein excretion and the renal function parameters including serum creatinine(Cre) and blo... |
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| Keywords: | tannic acid diabetic nephropathy intercellular adhesion molecule 1 tumor necrosis factor-α |
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