细胞因子在胃十二指肠疾病中的作用机理 |
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作者单位: | 1\ Dept.of Digestive Disease,The Second Clinical College; 2\ Dept. of Forensic Medicine,The School of Basic Medical Sciences |
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摘 要: | 目的:探讨细胞因子在胃十二指肠疾病中的作用机理。方法:应用 E L I S A 法对30例慢性浅表性胃炎(急性期)、30例消化性溃疡患者胃粘膜组织中细胞因子 I L 1、 I L 8及 T N F α活性进行了测定。结果:慢性急性期浅表性胃炎患者胃粘膜中 I L 1、 I L 8及 T N F α活性明显高于对照组( P<001);消化性溃疡患者明显高于对照组( P< 001);幽门螺杆菌阳性疾病组明显高于阴性疾病组( P< 001);其中消化性溃疡组 I L 8活性明显高于慢性胃炎组( P< 001)。结论:细胞因子在慢性胃炎、消化性溃疡疾病发生发展中起一定作用。
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关 键 词: | 慢性浅表性胃炎 消化性溃疡 细胞因子 幽门螺杆菌 |
修稿时间: | 1998年8月21日 |
Study on active mechanism of cellular factor in gastric and duodenal disease |
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Authors: | Li Dongfu Sun Fushan Yu Jianxun Tai Jinhua Zhang Guorong Duan Yaqing |
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Institution: | Li Dongfu 1,Sun Fushan 1,Yu Jianxun 1,Tai Jinhua 1,Zhang Guorong 1,Duan Yaqing 2 |
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Abstract: | Objective:To study on active mechanism of cellular factor in gastric and duodenal disease.Methods:The activity of mucosal interleukin 1 (IL 1),interleukin 8 (IL 8) and tumor necrosis factor alpha (TNF α) of 30 patients with chronic gastritis and 30 patients with peptic ulcer was detected by ELISA methods.Results:Activity of IL 1,IL 8 and TNF α of mucosa of patients with chronic gastritis was 602.85±254.99,493.53±137.72,424.15±28.40 respectively which were significantly higher than those of normal controls;IL 1,IL 8 and TNF α activity in the mucosa of patients with peptic ulcer was 586.25±137.68,629.83±82.60,437.83±109.18 respectively which were significantly higher than those of normal controls,IL 1,IL 8 and TNF α activity in patients with Helicobacter pylori infection wa 639.40±184.89,584.53±125.85,456.19±51.56 respectively which were higher than those in patients with no Helicobacter pylori infection,and IL 8 activity of patients with peptic ulcer was higher than that of chronic gastritis.Conclusion:There were relationships between IL 1,IL 8 and TNF α activity,and mucosa damage of gastric and duodenal disease. |
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Keywords: | chronic gastritis peptic ulcer cellular factor |
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