| HpD—激光对动物瘤体的细胞化学影响(选用细胞色素氧化酶、琥珀酸脱氢酶、酸性磷酸酶显示法) |
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| 引用本文： | 兰继毓,陈爱军,钱慧珠,赵淮辉.HpD—激光对动物瘤体的细胞化学影响(选用细胞色素氧化酶、琥珀酸脱氢酶、酸性磷酸酶显示法)[J].吉林大学学报(医学版),1985(2). |
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| 作者姓名： | 兰继毓 陈爱军 钱慧珠 赵淮辉 |
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| 作者单位： | 白求恩医科大学组织胚胎教研室
(兰继毓，陈爱军)，白求恩医科大学原四院激光室
(钱慧珠)，白求恩医科大学原四院激光室(赵淮辉) |
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| 摘 要： | 本文为研究HpD-激光破坏恶性肿瘤的机理,采用细胞化学方法观察了小白鼠肿瘤中细胞色素氧化酶、琥珀酸脱氢酶和酸性磷酸酶的活性。在HpD-激光处理瘤细胞后12小时细胞色素氧化酶活性明显降低,24小时即消失。然而,琥珀酸脱氢酶和酸性磷酸酶无明显变化。结果表明,HpD-激光破坏恶性肿瘤的原因之一,乃是抑制了瘤细胞内的细胞色素氧化酶活性,进而阻断了呼吸链。
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| 关 键 词： | 血卟啉衍生物—激光 肿瘤 酶 |
Cytochemical effect of animal tumors by hematoporphyrin derivative-Photodynamic therapy with application of CHO, SDH and ACH showing |
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| Lan Jiyu et al.Cytochemical effect of animal tumors by hematoporphyrin derivative-Photodynamic therapy with application of CHO, SDH and ACH showing[J].Journal of Jilin University: Med Ed,1985(2). |
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| Authors: | Lan Jiyu |
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| Institution: | Lan Jiyu et al |
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| Abstract: | Enzyme activity of cytochrome oxidase, succinic dehydrogenase and acid pho-sphatase was observed by using cytochemistry method in rat tumors in order to study the mechanism of Hematoporphyrin derivative-photodynamic therapy (HpD-PdT) to destroy malignant tumors.Enzyme activity of cytochrome oxidase decreased significantly at 12 hours and disappeared at 24 hours after exposure of tumor cells to HpD-PdT technique.However, the enzyme activity of both succinic dehydrogenase and acid phosphatase was not obviously changed.It shows that destruction of malignant tumors by HpD-PdT might be due to inhibition of cytochrome oxidase and interruption of respiratory chain in the tumor cells. |
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| Keywords: | HpD-PdT Tumor Enzyme |
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