| 纳米SiO2颗粒在HepG2细胞中的分布及其细胞毒性 |
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| 引用本文： | 孙磊,李阳,刘晓梅,杜忠君,金明华,孙志伟.纳米SiO2颗粒在HepG2细胞中的分布及其细胞毒性[J].吉林大学学报(医学版),2011,37(2):236-240. |
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| 作者姓名： | 孙磊 李阳 刘晓梅 杜忠君 金明华 孙志伟 |
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| 作者单位： | 吉林大学公共卫生学院卫生毒理学教研室,吉林,长春,130021;吉林大学公共卫生学院卫生毒理学教研室,吉林,长春,130021;首都医科大学公共卫生与家庭医学学院卫生毒理与卫生化学系,北京,100069 |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金课题，科学前沿与交叉学科创新项目资助课题 |
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| 摘 要： | 目的:检测纳米SiO2颗粒作用于HepG2细胞后纳米颗粒的细胞摄取、分布情况及颗粒对细胞的毒性作用,初步探讨纳米颗粒的摄取、分布与细胞毒性的关系.方法:采用透射电镜(TEM)及动态光散射法检测纳米SiO2颗粒的表征;纳米SiO2颗粒作用HepG2细胞后,用荧光显微镜及TEM观察纳米SiO2颗粒的细胞摄取及细胞内分布情况...
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| 关 键 词： | 纳米SiO2颗粒 细胞内分布 线粒体 细胞毒性 |
| 收稿时间： | 2010-12-08 |
Distribution of silica nanoparticles in HepG2 cells and its relationship with cytotoxicity |
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| SUN Lei,LI Yang,LIU Xiao-mei,DU Zhong-jun,JIN Ming-hua,SUN Zhi-wei.Distribution of silica nanoparticles in HepG2 cells and its relationship with cytotoxicity[J].Journal of Jilin University: Med Ed,2011,37(2):236-240. |
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| Authors: | SUN Lei LI Yang LIU Xiao-mei DU Zhong-jun JIN Ming-hua SUN Zhi-wei |
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| Institution: | 1. Department of Health Toxicology| School of Pubilc Health| Jilin University| Changchun 130021|China；2. Department of Toxicology and Sanitary Chemistry,School of Public Health and Family Medicine,Capital Medical University,Beijing 100069,China |
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| Abstract: | Objective To detect the cell uptake and intracellular distribution of silica nanoparticles in HepG2 cells after treated with silica nanoparticles and the cytotoxicity of HepG2 cells caused by the particles and discuss the relationship between intracellular distribution of nanoparticles and cytotoxicity.Methods The size,shape and dispersibility of silica nanoparticles were detected by transmission electron microscope(TEM) and dynamic light scattering method.The cell uptake and intracellular distribution of s... |
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| Keywords: | silica nanoparticles intracellular distribution mitochondria cytotoxicity |
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