刺五加叶皂苷对实验性脑缺血大鼠血液流变学及血小板功能的影响

目的：观察刺五加叶皂苷（ASS）对实验性脑缺血大鼠血液流变学及血小板功能的影响。 方法：大鼠连续腹腔注射ASS 25、50和100 mg•kg^-1 3 d后，结扎双侧颈总动脉伴低血压制作实验性脑缺血模型，15 min后测定大鼠血液流变学各参数、血小板粘附及聚集功能等指标。结果：ASS 50、100 mg•kg^-1均能明显降低实验性脑缺血大鼠全血粘度、血浆粘度、血浆纤维蛋白原浓度、血沉、红细胞压积、红细胞聚集指数、红细胞刚性指数及抑制血小板粘附、聚集功能(P<0.05～P<0.001)。结论：ASS对实验性脑缺血大鼠血液流变学及血小板功能的异常变化有明显的改善作用。

Effects of Acanthopanax senticosus saponins (ASS) on hemorrheology and platelet function in experimental cerebral ischemia rats

Objective To observe the effects of Acanthopanax senticosus saponins (ASS) on hemorrheology and platelet function in experimental cerebral ischemia rats. Methods The cerebral ischemia model induced by bilateral common carotid artery clamping and controlled hemorrhage to a mean arterial pressure of 50 mmHg was produced in rats treated by continuous intraperitoneal injection of ASS with dosages of 25,50,100 mg·kg -1 for 3 days. The effects of ASS on the hemorrheology and platelet aggregation and adhesion functions were measured after 15 min. Results ASS with dosages of 50 and 100 mg·kg -1 decreased the blood viscosity,plasma viscosity, plasma fibrinogen concentration,erythrocyte sedimentation,hematocrit, erythrocyte aggregation index, and erythrocyte rigidity index markedly,and inhibited platelet aggregation and adhesion functions. Conclusion ASS can improve evidently abnormal changes of hemorrheology and platelet functions in experimental cerebral ischemia rats.