| 病毒性心肌炎患儿血清IL-4和IFN-γ含量变化的临床意义 |
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| 引用本文： | 赵凯姝,鲁继荣,乔红梅,刘文东,刘文斌.病毒性心肌炎患儿血清IL-4和IFN-γ含量变化的临床意义[J].吉林大学学报(医学版),2003,29(3):324-325. |
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| 作者姓名： | 赵凯姝 鲁继荣 乔红梅 刘文东 刘文斌 |
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| 作者单位： | 1. 吉林大学第一医院儿科,吉林,长春,130021
2. 山东省胶州市人民医院 |
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| 摘 要： | 目的 :探讨病毒性心肌炎患儿血清白细胞介素 - 4( IL- 4)和 γ干扰素 ( IFN- γ)含量变化及临床意义。方法 :采用双抗体夹心 ELISA方法检测 30例急性期和 1 5例迁延期患儿血清 IL- 4和IFN-γ含量 ,并分析二者的关系。结果 :急性期、迁延期患儿血清 IL- 4含量均低于正常对照组 ,IFN-γ含量高于正常对照组 ;急性期患儿血清 IL- 4和 IFN-γ呈显著负相关。结论 :病毒性心肌炎患儿血清 IL- 4含量降低 ,IFN-γ含量增高 ,体内 TH1应答强于 TH2 ,有利于疾病恢复
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| 关 键 词： | 心肌炎/诊断 白细胞介素4 干扰素Ⅱ型 |
| 文章编号： | 1671-587X(2003)03-0324-02 |
| 修稿时间： | 2002年7月16日 |
Evaluation of Serum IL-4 and IFN-γ Level in Child Patients with Viral Myocarditis |
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| Abstract: | Objective: To explore the changes and clinical evaluation of serum IL 4 and IFN γ contents in child patients with viral myocarditis. Methods:Sandwich ELISA was used to detect IL 4 and IFN γ contents in the sera from 30 cases in acute attack and 15 cases in deferred stage,respectively. The results of detection and the relationship between IL 4 and IFN γ were analyzed statistically. Results:The serum IL 4 contents were lower than those of the normal control group and IFN γ contents were higher than those of the normal control group both in acute attack and in deferred stage. Linearregression showed that the serum IL 4 content was negatively correlated to the IFN γ content. Conclusion:The serum IL 4 content decreased and IFN γ content increased in child patients with viral myocarditis. |
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| Keywords: | Myocarditis/diagnosis Interleukin 4 Interferon type Ⅱ |
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