| 刺五加皂苷的抗辐射损伤作用 |
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| 引用本文： | 陈月,王宝贵,张桂英,颜炜群.刺五加皂苷的抗辐射损伤作用[J].吉林大学学报(医学版),2005,31(3):423-425. |
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| 作者姓名： | 陈月 王宝贵 张桂英 颜炜群 |
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| 作者单位： | 1. 吉林大学药学院药物分析教研室，吉林 长春130021；2. 吉林大学公共卫生学院营养与食品卫生学教研室，吉林 长春130021；3. 吉林大学再生医学科学研究所生化研究室，吉林 长春130021 |
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| 摘 要： | 目的：探讨刺五加皂苷 (ASS)对X射线照射小鼠抗辐射损伤的作用。
方法：将小鼠50只随机均分为阴性对照组、阳性对照组及低、中、高剂量ASS实验组。测定小鼠脾指数、胸腺指数、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性，并测定淋巴细胞转化率和外周血白细胞数。
结果：3个ASS实验组小鼠各项指标与对照组比较，脾指数差异无显著性（P>0.05），胸腺指数、淋巴细胞刺激指数、血清SOD和GSH-Px活性差异均有显著性（P<0.05）。
结论：ASS对辐射小鼠具有一定的抗辐射和抗氧化作用。
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| 关 键 词： | 皂苷类 辐射损伤 实验性 |
| 文章编号： | 1671-587X(2005)03-0423-03 |
| 收稿时间： | 2004-11-15 |
| 修稿时间： | 2004年11月15日 |
Protective effects of acanthopanax senticosus saponins on mice with irradiation damage induced by X-rays |
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| CHEN Yue,WANG Bao-gui,ZHANG Gui-ying,YAN Wei-qun.Protective effects of acanthopanax senticosus saponins on mice with irradiation damage induced by X-rays[J].Journal of Jilin University: Med Ed,2005,31(3):423-425. |
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| Authors: | CHEN Yue WANG Bao-gui ZHANG Gui-ying YAN Wei-qun |
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| Institution: | 1. Department of Pharmacy Analysis，School of Pharmacy，Jilin University，Changchun 130021,China;2. Department of Nutrition and Food Hygiene,School of Public Health，Jilin University， Changchun 130021，China;3. Department of Biochemistry，Institute of Frontier Medical Sciences，Jilin University， Changchun 130021，China |
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| Abstract: | Objective To evaluate the protective effects of acanthopanax senticosus saponins (ASS) on mice with irradiation damage induced by X-rays. Methods The mice were randomly divided into normal control group, irradiation control group and three experimental groups. Peripheral blood WBC and PLT were detected and accounted. The transformation test of lymphocytes was done and the spleen index (SI), thymus index (TI); the activities of superaxide dismulase (SOD) and GSH-Px in serum were determined. Results Compared with the control group, TI and the activities of SOD and GSH-Px in serum in three experimental groups were increased significantly (P<0.05). Conclusion ASS have protective effects on mice with irradiation damage induced by X-rays. |
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| Keywords: | acanthopanax senticosus saponins irradiation injuries experimental |
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