东北菱提取物对肝癌细胞的体内外抑制作用

目的：探索东北菱提取物对肝癌细胞体内外抑制作用。方法：采用³H-TdR掺入法分别测定东北菱醇提取物和水提取物对肝癌细胞的体外敏感性；对荷瘤小鼠进行体内实验，观察该提取物对肝癌细胞生长的抑制率。结果：体外实验当剂量达225.00 g?L^-1时，抑制率为75.49%；体内实验抑瘤率为60%以上。结论：东北菱不同溶剂提取物均具有抑制肝癌细胞的作用。

Inhibitory effects of extracts from Trapa manshurica Fler.on liver cancer cells in vivo and in vitro

Objective To explore the inhibitory effects of extracts from Trapa manshurica Fler. on liver cancer cells in vivo and in vitro. Methods The sensitivity of extracts from Trapa manshurica Fler. to liver cancer cells in vitro was determined with 3H-TdR incorporation method. The inhibitory rate and growth of the tumor and the weight change of the mice were observed. Results When the dosage was 225.00 g·L -1, the inhibitory rate of tumor was 75.49% in vitro and the inhibitory rate of tumor was 60% in vivo. Conclusion The extracts from Trapa manshurica Fler. has the inhibitory effects on tumor.