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氟替卡松/沙美特罗对哮喘患者外周血单个核细胞中辅助性T细胞亚群及气道炎症的影响
引用本文:侯松萍,李立,于倩.氟替卡松/沙美特罗对哮喘患者外周血单个核细胞中辅助性T细胞亚群及气道炎症的影响[J].吉林大学学报(医学版),2011,37(3):529-533.
作者姓名:侯松萍  李立  于倩
作者单位:吉林大学中日联谊医院呼吸科,吉林,长春,130033;吉林大学中日联谊医院药剂科,吉林,长春,130033
基金项目:中华医学会临床医学慢性呼吸道疾病科研专项基金资助课题(07010040012)
摘    要:目的:探讨氟替卡松/沙美特罗对哮喘患者外周血单个核细胞中辅助性T细胞亚群(Th)及气道炎症的影响,为其临床治疗哮喘提供理论依据.方法:13例慢性持续期中度哮喘患者,给予氟替卡松/沙美特罗连续治疗1.5和3.0个月.检测治疗前后外周血Th亚群(Th1、Th2和Th3)、血清细胞因子及IgE水平,观察诱导痰炎症细胞的变化和...

关 键 词:支气管哮喘  辅助性T细胞亚群  细胞因子  气道炎症  氟替卡松  沙美特罗
收稿时间:2011-01-05

Effects of fluticasone/salmeterol on peripheral blood TH subsets and airway inflammation in patients with asthma
HOU Song-ping,LI Li,YU Qian.Effects of fluticasone/salmeterol on peripheral blood TH subsets and airway inflammation in patients with asthma[J].Journal of Jilin University: Med Ed,2011,37(3):529-533.
Authors:HOU Song-ping  LI Li  YU Qian
Institution:1. |Department of Respiratory Medicine|China-Japan Union Hospital,Jilin University|Changchun 130033|China;2. Department of Pharmacy,China-Japan Union Hospital,Jilin University|Changchun 130033|China
Abstract:Objective To explore the effects of fluticasone/salmeterol on T helper cell(Th) subsets in peripheral blood and airway inflammation in patients with asthma and provide a theoretical basis for their clinical application in treatment of asthma.Methods 13 patients with chronic persistent moderate asthma received 250 μg fluticasone/50 μg salmeterol inhalation(twice daily) for 1.5 and 3.0 months.The changes of peripheral Th subsets and the levels of their cytokines and IgE in serum were detected,the inflammatory cells in induced sputum and the clinical effects in patients with asthma treated by fluticasone/salmeterol were observed.Results Compared with before treatment,after treatment of 1.5 months in patients with asthma:the percentage of Th3 was increased(P<0.05),the percentage of Th2 was decreased(P<0.05),the TGF-β and IL-4 had no significant change in the peripheral blood(P>0.05);the eosinophils(eos) in sputum was significantly decreased(P<0.01),the eos in blood and neutrophils in sputum had no significant change;the PEF and ACT scores were increased(P<0.01),the PEF variability was decreased(P<0.01),the use frequency of rescue medications for daily had no significant decrease;after treatment of 3.0 months:the Th1,Th1/Th2 and Th3 were increased,the Th2 was decreased(P<0.05 or P<0.01);the IL-4 and TGF-β were decreased(P<0.05),the IFN-γ was increased(P<0.05);the level of IgE had no significant change;the eos in blood,eos and neutrophils in sputum were decreased(P<0.01);the PEF and ACT scores were increased,the PEF variability was decreased(P<0.01),the use frequency of rescue medications for daily was decreased(P<0.01);and the PEF variability was continuously decreased,the ACT were continuously increased(P<0.01)after treatment of 3.0 months compared after treatment of 1.5 months.Conclusion Fluticasone/salmeterol can increase the numbers of Th3 cells in peripheral blood of patients with asthma,correcte the imbalances of Th1/Th2 ratio,reduce asthmatic airway inflammation and clinical symptoms in a time-dependent manner.
Keywords:bronchial asthma  T helper cell subsets  cytokine  airway inflammation  fluticasone  salmeterol  
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