沙棘对麻醉开胸犬心肌氧代谢的影响

目的：探讨沙棘对麻醉开胸犬冠脉血流量等心肌氧代谢指标的影响。方法：将24只犬随机分为对照组、沙棘4和16 mg•kg^-1剂量组以及阳性对照药舒血宁组。制备麻醉开胸犬，股静脉注射给药，测量血压、心率及冠状动脉血流量，并计算冠状动脉阻力、心肌氧摄取率、心肌耗氧指数及心肌耗氧量。结果：与对照组比较，沙棘4和16 mg•kg^-1剂量组犬冠脉血流量明显增加（P<0.05或 P<0.01），冠状动脉阻力降低（P<0.05或 P<0.01），心肌氧摄取率减少（P<0.05或P<0.01），但心肌耗氧指数及心肌耗氧量差异无显著性（P>0 .05）。结论：沙棘具有明显改善麻醉开胸犬心肌氧代谢的作用。

Effects of ShaJi on oxygen metabolism in myocardium of anesthetized thoraco-opened dogs

Objective To study the effects of ShaJi on the indexes of oxygen metabolism such as coronary blood flow in myocardium of anesthetized thoraco-opened dogs. Methods Dogs were randomly divided into control group,4 and 16 mg·kg-1 ShaJi groups,and positive control group(n=6).The anesthetized thoraco-opened dog models were set up.The administration of intravenous injection was used by femoral vein.The blood pressure,heart rate and coronary blood flow(CBF) were measured.Coronary resistance,myocardial oxygen uptake rate,myocardial oxygen consumption index and myocardial oxygen consumption were calculated.Results Compared with control group,the CBF was increased (P<0.05 or P<0.01),the coronary resistance was reduced (P<0.05 or P<0.01) and the myocardial oxygen uptake rate was decreased in 4 and 16 mg·kg-1 ShaJi groups (P<0.05 or P<0.01). But ShaJi had no noticeable effects on myocardial oxygen consumption index and myocardial oxygen consumption compared with control (P>0.05).Conclusion ShaJi can significantly ameliorate oxygen metabolism in myocardium of anesthetized thoraco-opened dogs.