结核性胸膜炎病人局部T淋巴细胞对B淋巴细胞产生抗PPD抗体水平调节作用的观察 |
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引用本文: | Gong Zhaodi,Huang Jin,Wang Ke,Li Shufang.结核性胸膜炎病人局部T淋巴细胞对B淋巴细胞产生抗PPD抗体水平调节作用的观察[J].吉林大学学报(医学版),1998(3). |
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作者姓名: | Gong Zhaodi Huang Jin Wang Ke Li Shufang |
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作者单位: | 1\ Dept.of ICU,The First Clinical College;2\ Dept.of Respiration,The Second Clinical College |
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摘 要: | 目的:观察结核性胸膜炎病人胸水中T淋巴细胞及正常人血清中T淋巴细胞对B淋巴细胞抗PPD抗体产生的影响。方法:应用体外细胞培养的方法,常规ELISA间接法检测B、B+P、B+T和B+P+T四组培养上清中抗PPDIgG水平。结果:健康人T淋巴细胞对B细胞及含PPD的B细胞产生抗PPD抗体无明显影响;而结核性胸膜炎病人病变局部T细胞在无PPD存在的情况下对B细胞产生抗PPD抗体无抑制作用,反而能辅助其抗体的产生,而在PPD存在的情况下,T细胞明显抑制B细胞产生抗PPDIgG。结论:结核性胸膜炎病人T淋巴细胞使B+P组产生抗PPDIgG水平下降的原因不是B细胞本身分泌免疫球蛋白功能受损,而是功能上受抑制。抑制的因素不是来自于T淋巴细胞本身,而是PPD抗原的间接作用
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关 键 词: | 胸水 PPD 抗体 T淋巴细胞 B淋巴细胞 |
Effect of local T lymphocytes of tuberculosis exudative pleurisy patients on B lymphocytes in producingan anti-PPD antibodies |
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Abstract: | Objective:To detect the anti-PPD IgG levels in the supernate of B,B+T,B+P and B+P+T groups.Methods:The observation was performed after culture in vitro for 3 days at the cell level.Results:T lymphocytes of control group did not significantly affect the production of PPD antibody in both B and B+P groups (P>01,025,respectively).But T lymphocytes of tubeculosis exudative plurisy patients did not inhibit the production of anti-PPD antibody themselves.On the opposite they obviously promoted the secretion of antibody (P<005). In the presence of PPD antigen the production of IgG to PPD decreased (P<005).Conclusion:It was PPD antigen that activated T lymphocytes and indirectly inhibited the production of PPD antibodies through T cells. |
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Keywords: | thoracic fluid PPD antibody T lymphocyte B lymphocyte |
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