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脾虚和肾虚雌性大鼠生育能力的实验观察
引用本文:周英.脾虚和肾虚雌性大鼠生育能力的实验观察[J].广州中医药大学学报,1998,15(3):195-199.
作者姓名:周英
作者单位:广州中医药大学
摘    要:为系统观察脾虚和肾虚雌性SD大鼠的生育能力,将大鼠随机分为:脾虚组、脾虚复健组、肾虚组、肾虚复健组、正常组。脾虚组和肾虚组分别按常规方法用利血平和羟基脲制成脾虚模型和肾虚模型。虚证动物模型出现与人类相似的症状:动情周期紊乱,甚至消失;生殖器官萎缩;血清卵泡刺激素(FSH)、雌二醇(E2)水平下降;子宫腺体数目减少,卵巢次级和成熟卵泡数减少,生育能力下降。而肾虚大鼠上述变化更显著。用四群子喂饲脾虚模

关 键 词:生育力  药物作用  肾虚  肾气丸  脾虚  中医药疗法

Genitality in SD Rats with Spleen Deficiency and Kidney Deficiency
Zhou Ying.Genitality in SD Rats with Spleen Deficiency and Kidney Deficiency[J].Journal of Guangzhou University of Traditional Chinese Medicine,1998,15(3):195-199.
Authors:Zhou Ying
Institution:advisors: Liang Guozhen Luo Songping
Abstract:Genitality in female SD rats with spleen deficiency and kidney deficiency was observed systematically. The spleen-deficiency rat(SDR) model was set up with injection of reserpine and kidney_deficiency rat (KDR) model by gastric infusion of hydroxycarbamide. Si Junzi Tang and Shenqi Tang were used to recover the SDR and KDR respectively. Rats were allocated to five groups: SDR group, Si Junzi Tang SDR group, KDR group,Shenqi Tang KDR group and normal control group. It was found that results in the rats with deficiency syndromes were similar to those in human being,for instance, sexual cycle became irregular or even disappeared; genital organs went atrophy; the level of serum FSH and estradiol decreased; the numbers of uterine glands, secondary follicle and mature follicle lowered and the genitality decreased. The above changes occurred in the KDR especially. Symptoms in the deficiency syndromes were improved by invigorating the spleen and tonifying the kidney. The genitality was obviously increased in Shenqi Tang KDR group. It is indicated that in SDR the digestive function is affected directly and the endocrine function indirectly (including hypothalamus_hypophysis_gonad axis,i.e.,HHG axis), while in KDR, HHG axis is affected directly. Both Si Junzi Tang and Shenqi Tang can regulate HHG axis. The theory of deficiency spleen involving the kidney and the kidney controlling the genitality in TCM was also discussed.
Keywords:FERTILITY/drug eff    KIDNEY DEFICIENCY  SHENQI PILL  SPLEEN DEFICIENCY  SIJUNZI DECOCTION  WOMEM(FEMALE)  DISEASE MODEL  ANIMAL  RATS
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