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通脉口服液对慢性肾炎气虚血瘀证大鼠模型的药效学研究
引用本文:杨霓芝,包崑,王立新,王桦,雷娓娓. 通脉口服液对慢性肾炎气虚血瘀证大鼠模型的药效学研究[J]. 广州中医药大学学报, 2000, 17(4): 332-336
作者姓名:杨霓芝  包崑  王立新  王桦  雷娓娓
作者单位:1. 广州中医药大学第二附属医院,广州,510120
2. 广州空军总医院中医科,广州
3. 广州中医药大学电镜室,广州,510405
基金项目:广东省重点科技攻关项目!(编号 :970 5 3)
摘    要:目的:探讨益气活血药通脉口服液(由黄芪、三七组成)对大鼠慢性肾炎“气虚血瘀证”模型的治疗机理。方法:在大鼠慢性肾炎模型的基础上,加建大鼠“气虚血瘀证”模型,随机分通脉口服液高剂量治疗组、通脉口服液低剂量治疗组、金水宝治疗组、模型对照组及正常对照组,治疗4周后,进行组间疗效比较。结果:通脉口服液组对模型大鼠的一般状态、生化指标(包括T淋巴细胞亚群和血液流变学等)及肾组织病理的损害均有明显的改善作用,

关 键 词:慢性肾炎 血瘀证 中医药疗法 通脉口服液
修稿时间:2000-08-50

Pharmacodynamic Study of Tongmai Oral Liquid for Chronic Nephritis Rat Model with Qi-deficiency and Blood-stasis Syndrome
YANG Nizhi,BAO Kun,WANG Lixing,WANG Hua,LEI Weiwei. Pharmacodynamic Study of Tongmai Oral Liquid for Chronic Nephritis Rat Model with Qi-deficiency and Blood-stasis Syndrome[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2000, 17(4): 332-336
Authors:YANG Nizhi  BAO Kun  WANG Lixing  WANG Hua  LEI Weiwei
Affiliation:YANG Nizhi 1,BAO Kun 1,WANG Lixing 1,WANG Hua 2,LEI Weiwei 3
Abstract:The mechanism of Tongmai Oral Liquid (TOL) for chronic nephritis rat model with Qi-deficiency and blood-stasis syndrome was studied.The model was established by adding Qi-deficiency and blood-stasis syndrome to the chronic nephritis rats. The experimental rats were randomly allocated to 5 groups: Group A (treated with high dosage of TOL), Group B (treated with low dosage of TOL), Group C (treated with Jinshuibao), Group D (model control group) and Group E (normal control group). After 4 weeks of treatment, general health state, biochemical indexes including T lymphocyte subgroup and blood rheology, and pathological damage of kidney tissue were much improved in Group A than Group B and Group C. It is indicated that TOL can improve the renal function and delay the occurrence of glomerular arteriosclerosis in rats by reinforcing Qi, activating blood flow, regulating immune function, lessening the hypercoagulative state and reducing renal damage.
Keywords:TONGMAI ORAL LIQUID/pharmacology  ASTRAGALUS MEMBRANACEUS/ther. use  PANAX PSEUDOGINSENG/ther. use  NEPHRITIS/ TCD therapy  T-LYMPHOCYTES/immunology  BLOOD RHEOLOGY/drug effects  DISEASE MODELS   ANIMAL  RATS
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