| 补肾益智方对老年性痴呆大鼠突触传递长时程增强的影响 |
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| 引用本文： | 饶燕,赖世隆,胡镜清,王奇.补肾益智方对老年性痴呆大鼠突触传递长时程增强的影响[J].广州中医药大学学报,2000,17(2):109-112. |
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| 作者姓名： | 饶燕 赖世隆 胡镜清 王奇 |
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| 作者单位： | 广州中医药大学老年脑病研究所中心,广州,510405 |
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| 基金项目： | 国家“九五”科技重点攻关项目! (NO :96 - 90 6 - 0 9- 0 2 )，国家医药技术创新博士项目! (NO :98-B - 13) |
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| 摘 要： | 观察补肾益智方（蛇床子、枸杞子、女贞子、人参等组成）对老年性痴呆（又称阿尔茨海默病，Ａｌｚｈｅｉｍｅｒ’ｓ ｄｉｓｅａｓｅ，ＡＤ）模型大鼠突触传递长时程增强现象（ｌｏｎｇ－ｔｅｒｍ ｐｏｔｅｎｔｉａｔｉｏｎ，ＬＴＰ）的影响，旨在探讨该方治疗ＡＤ作用的神经生物学机制。应用Ｄ－半乳糖致亚急性衰老合并Ｍｅｙｎｅｒｔ基底核损毁建立ＡＤ模型大鼠，用补肾智方对ＡＤ大鼠灌胃治疗４周，采用电生理学方法，检测大鼠海
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| 关 键 词： | 老年性痴呆 中医药疗法 补肾益智方 突出传递 |
Effects of Bushen Yizhi Decoction on Hippocampal Long term Potentiation in Rat Model with Alzheimer's Disease |
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| RAO Yan,LAI Shilong,HU Jingqing,WANG Qi.Effects of Bushen Yizhi Decoction on Hippocampal Long term Potentiation in Rat Model with Alzheimer''''s Disease[J].Journal of Guangzhou University of Traditional Chinese Medicine,2000,17(2):109-112. |
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| Authors: | RAO Yan LAI Shilong HU Jingqing WANG Qi |
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| Abstract: | To explore the effects of Bushen Yizhi Decoction(BYD)on the hippocampal long_term potentiation (LTP) in rat model with Alzheimer's disease(AD),AD rat model was established by intraperitoneral injection of D_galactose and ibotenic acid injection into nucleus basalis of Meynert.Electrophysiological method was used to assess the changes of long_term potentiation of dentate gyrus.BYD groups were treated with gastric infusion of BYD for 4 weeks.The results showed that the differences of potentiation of excited postsynaptic potentials(EPSPs)were not significant among the five groups (P> 0.05 ),and potentiation of population spike(PS)amplitude in BYD groups were significantly different from AD model group.It is suggested that BYD exerts an effect in improving hippocampal LTP in rat model of AD. |
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| Keywords: | ALZHEIMER'S DISEASE/TCD therapy DEMENTIA SENILE/TCD therapy KIDNEY_REINFORCING DRUGS/ther use @BUSHEN YIZHI DECOCTION/pharmacology HIPPOCAMPUS/drug effects @SYNAPTIC TRANSMISSION/drug effects DISEASE MODELS ANIMAL RATS (original ar |
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