| 不同证候的注意缺陷多动障碍患儿多巴胺D2受体基因携带情况检测 |
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| 引用本文： | 李宜瑞,陈晓刚,李迎敏,徐秋英,黄福群,詹淑英.不同证候的注意缺陷多动障碍患儿多巴胺D2受体基因携带情况检测[J].广州中医药大学学报,1999,16(1):17-20. |
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| 作者姓名： | 李宜瑞 陈晓刚 李迎敏 徐秋英 黄福群 詹淑英 |
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| 作者单位： | 广州中医药大学第一附属医院,广州,510405 |
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| 基金项目： | 广东省中医药管理局资助 |
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| 摘 要： | 注意缺陷多动障碍（ａｔｔｅｎｔｉｏｎｄｅｆｉｃｉｔｈｙｐｅｒｃａｔｉｖｉｔｙｄｉｓｏｎｒｄｒ，ＡＤＨＤ）是常见的儿童行为障碍，目前病因尚未明确，国外近年由于分子生物学方法的介入，发现多巴胺Ｄ２受体ＴａｑＩＡ１等位基因与本病相关，通过对广州市城镇学龄儿童多巴胺Ｄ２受体基因ＴａｑＩＡ多态性的检测，支持Ａ１等位基因与本病的关系（Ｐ＝０．００６５２０）并发现病该基因与中医辨证的“肾虚肝亢”证候关系更为密切
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| 关 键 词： | 轻微脑损伤综合征/病理生理学 受体 多巴胺D2 心脾两虚/中医病机 肾虚火动/中医病机 儿童 |
Determination of Dopamine D2 Receptor Gene in Attention Deficit Hyperactivity Disorder with Different TCM Syndrome |
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| LI Yi-rui,CHEN Xiao-gang,LI Ying-min,XU Qiu-ying,HUANG Fu-qun,ZHAN Shu-ying.Determination of Dopamine D2 Receptor Gene in Attention Deficit Hyperactivity Disorder with Different TCM Syndrome[J].Journal of Guangzhou University of Traditional Chinese Medicine,1999,16(1):17-20. |
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| Authors: | LI Yi-rui CHEN Xiao-gang LI Ying-min XU Qiu-ying HUANG Fu-qun ZHAN Shu-ying |
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| Abstract: | Attention deficit hyperactivity disorder(ADHD)is a common behavior disorder in children and its pathogenesis remains unknown.It has been reported in foreign literature that the A 1 allele of the Taq I polymorphism of the dopamine D 2 receptor gene(DRD 2)was related to ADHD.In this study,the school_age children were examined by the above technique,and the results supported the relationship between the allelic gene and ADHD(P=0.006520),especially those with the syndrome of kidney deficiency and liver hyperactivity(P=0.000122)while not related to those with the syndrome of deficiency of heart and spleen(P=0.910952).This may supply a genetic basis for the syndrome differentiation of ADHD in TCM. |
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| Keywords: | ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY/physiopathol RECEPTOR DOPAMINE D 2 HEART_SPLEEN DEFICIENCY/pathogen(tcm) KIDNEY DEFICIENCY FIRE/pathogen(tcm) CHILD |
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