首页 | 本学科首页   官方微博 | 高级检索  
检索        

理脾化痰方对食饵性动脉粥样硬化症家兔血管平滑肌细胞增殖和凋亡的调控
引用本文:赵学军,李任先,刘国普,赵立诚,徐勤,郑高飞.理脾化痰方对食饵性动脉粥样硬化症家兔血管平滑肌细胞增殖和凋亡的调控[J].广州中医药大学学报,2001,18(2):144-148.
作者姓名:赵学军  李任先  刘国普  赵立诚  徐勤  郑高飞
作者单位:1. 广州中医药大学新药开发研究中心,
2. 广州中医药大学,
基金项目:广东省科委科研基金资助项目!(编号 :SKF - 96 - 0 4)
摘    要:【目的】探讨由法半夏、白术、天麻、橘红、丹参等组成的理脾化痰方抗早期动脉粥样硬化症(atherosclerosis,AS)的可能性和作用机制。【方法】通过组织形态学 (包括光镜和电镜 )、免疫组化和TUNEL等方法观察了该方对食饵性动脉粥样硬化症家兔脂纹脂斑期主动脉内膜形态和相对厚度、血管平滑肌细胞 (vascularsmoothmusclecells ,VSMCs)ki- 6 7和凋亡细胞阳性率的影响。【结果】理脾化痰方确能阻抑早期AS的形成 ,观察组主动脉内膜相对厚度小于模型组 (P <0 .0 5) ,VSMCski- 6 7的表达率和凋亡的VSMCs阳性率均低于模型组 (P <0 .0 5)。【结论】该方抗早期AS的机制与其同时抑制VSMCs的增殖和过高水平的凋亡有关。

关 键 词:理脾化痰方  药理学  动脉粥样硬化症  中医药疗法  细胞增殖  细胞凋亡  血管平滑肌细胞
文章编号:1007-3213(2001)02-0144-05
修稿时间:2000年12月18

Effects of Lipi Huatan Formula on Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Rabbits with Early Dietary Atherosclerosis
ZHAO Xuejun ,LI Renxian ,LIU Guopu ,ZHAO Licheng ,XU Qing ,ZHENG Gaofei.Effects of Lipi Huatan Formula on Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Rabbits with Early Dietary Atherosclerosis[J].Journal of Guangzhou University of Traditional Chinese Medicine,2001,18(2):144-148.
Authors:ZHAO Xuejun  LI Renxian  LIU Guopu  ZHAO Licheng  XU Qing  ZHENG Gaofei
Institution:ZHAO Xuejun 1,LI Renxian 2,LIU Guopu 2,ZHAO Licheng 2,XU Qing 2,ZHENG Gaofei 2
Abstract:Objective To explore the possibility of Lipi Huatan Formula (LHF) in inhibit ing the occurrence of early atherosclerosis and its mechanism. Methods Twent y_four rabbits were randomly allocated to Group A (normal control), Group B (mod el control) and Group C (treated with LHF). Rabbit models with early dietary ath erosclerosis were induced by the feeding of fatty food. The morphological featur es and relative thickness of aortic intima, ki_67 expression of vascular smooth muscle cells (VSMCs) and the positive ratio of apoptotic VSMCs were observed by mo rphological, immunohistochemical and TUNEL techniques. Results The relative thickness of aortic intima, ki_67 expression of VSMCs and the positive ratio o f apoptotic VSMCs were decreased in Group C as compared with Group B (P < 0.05 ). Conclusion LHF can inhibit the occurrence of e arly atherosclerosis and its mechanism may be related to the inhibition of proli feration and apoptosis of VSMCs.
Keywords:LIPI HUATAN FORMULA/pharmacology  LIPI HUATA N FORMULA/ther  use  ATHEROSCLEROSIS/TCD therapy  VASCULAR SMOOTH MUSCLE CELLS/drug effects  VASCULAR INTIMA/drug effects  MUSCLE  SMOOTH  VASCULAR/drug effects
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号