猴免疫缺陷病毒(SIV)慢性感染猴模型的建立

目的：在先前已建立了模拟人艾滋病感染者和患者的猴免疫缺陷病毒（ＳＩＶ）急性感染猴和中、晚期猴艾滋病（ＳＡＩＤＳ）模型的基础上，再摸索建立ＳＩＶ慢性感染猴模型，以期为抗区滋病药物的体内药效学介研究提供更合适的动物模型。方法：用ＳＩＶｍａｃ２５１感染恒河猴１７只，追踪观察其临床表现，体征变化，病程进展，血浆和全血病毒症规律，淋巴细胞亚群ＣＤ４的动态等。结果：临床体征有特征性，病程较长，１年内死亡２只（

Establishment of Monkey Model with Chronic Infection of Simian Acquired Immunodeficiency Virus

Further exploration of the establishment of monkey model chronically infected with Simian acquired immunodeficiency virus (SIV) was conducted on the basis of previous studies of SIV monkey models and simian acquired immunodeficiency syndrome models. Seventeen Rhesus monkeys were infected with SIVmac?251. Items such as symptoms and signs, course of infection,plasma viremia and the whole blood, changes of CD 4 lymphocyte subgroup were observed periodically. The results showed that specific clinical manifestations occurred, disease course prolonged and 2 of 17 monkeys died of severe immunodeficiency. Plasma viremia reached the peak on 14th day after infection, began to decrease on 21st day, and remained low titer or underdetermined from 60th to 360th day. Whole blood viremia reached high titer from 10th to 90th day, and over half of the monkeys maintained high viremia level up to 9th month and then decreased afterwards. CD 4 lymphocyte level decreased from 14th to 30th day, and then increased. The above changes of clinical manifestations, virology and immunology are similar to cases with chronic infection of human immunodeficiency virus (HIV) in the early stage. And this will provide a suitable animal model for the research of anti-AIDS drugs.