| 湿热证缠绵难愈的病理机制探讨 |
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| 引用本文： | 吴智兵,彭胜权,林培政,钟嘉熙,舒彤.湿热证缠绵难愈的病理机制探讨[J].广州中医药大学学报,2002,19(1):24-26. |
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| 作者姓名： | 吴智兵 彭胜权 林培政 钟嘉熙 舒彤 |
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| 作者单位： | 1. 广州中医药大学温病教研室,广州,510405
2. 广州中医药大学第二附属医院,广州,510405 |
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| 基金项目： | 广东省自然科学基金资助课题(编号:990356) |
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| 摘 要： | 目的：探讨湿热病湿热证病邪易滞留气分，缠绵难愈的病理机制。方法：以肥甘饮食造成高脂血症模型，观察注射内毒素后模型动物新西兰白兔的α－肿瘤坏死因子、白细胞介素－1的分泌情况。结果：肥甘饮食使新西兰白兔形成高脂血症后，致内毒素诱导的α－肿瘤坏死因子、白细胞介素－1分泌峰值降低，但消退延缓。结论：提示温病湿热病邪致病，不仅仅是湿邪和热邪病理性质的简单相加，还存在湿邪和热邪相互影响、蕴蒸合化的过程。
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| 关 键 词： | 病机 湿热证 病理机制 高脂血症 肿瘤坏死因子 |
| 文章编号： | 1007-3213(2002)01-0024-03 |
| 修稿时间： | 2001年9月5日 |
An Experimental Study on the Mechanism of Fever in Dmnp- Heat Syndrome |
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| WU Zhibing,PENG Shengquan,UN Peizheng,ZHONG Jiaxi,SHU Tong.An Experimental Study on the Mechanism of Fever in Dmnp- Heat Syndrome[J].Journal of Guangzhou University of Traditional Chinese Medicine,2002,19(1):24-26. |
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| Authors: | WU Zhibing PENG Shengquan UN Peizheng ZHONG Jiaxi SHU Tong |
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| Abstract: | Objective] To explore the mechanism of fever in damp- heat syndrome. Methods] Hyperlipemia rabbit models were established by feeding fatty - sweet diet. After the injection of endotoxin, the secretion of tumor necrosis factor and interleukin 1 was observed in rabbit model (Group A) and compared with normal rabbits (Group B) . Results] The peak of tumor necrosis factor and interleukin 1 secretion was decreased and the decline was slow in Group A. Conclusion ] The damp - heat syndrome in seasonal febrile disease is not merely a simple addition of damp and heat, but a result of retention and interaction of the two factors. |
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| Keywords: | SEASONAL PREVALENT DISEASES/TCM pathogenesis DAMP- HEAT SYNDROME/TCM pathogenesis HYPERLIPIDEMIA ENDOTOXINS TUMOR NECROSIS FACTOR/blood INTERLEUKIN-1/blood RABBITS DISEASE MODELS ANIMAL |
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