| 补肾益智方对阿尔茨海默病大鼠模型脑内胆碱能神经系统的保护作用 |
| |
| 引用本文： | 胡镜清,赖世隆,王奇,梁伟雄,谢红.补肾益智方对阿尔茨海默病大鼠模型脑内胆碱能神经系统的保护作用[J].广州中医药大学学报,1999,16(3):201-204. |
| |
| 作者姓名： | 胡镜清 赖世隆 王奇 梁伟雄 谢红 |
| |
| 作者单位： | 广州中医药大学DME中心,广州,510405 |
| |
| 基金项目： | 国家“九五”重点攻关课题 !编号 96- 90 6- 0 9- 0 2 |
| |
| 摘 要： | 为探讨自制方补肾益智方 (由蛇床子、枸杞子、女贞子、人参、制首乌等组成 )治疗阿尔茨海默病(Alzheimerdisease ,AD)的可能神经生物学机制 ,应用乙酰胆碱酯酶组织化学染色方法 ,研究了该方对D -半乳糖合并鹅膏蕈氨酸损毁大脑Meynert基底核的实验性阿尔茨海默病大鼠模型脑内胆碱能神经系统的保护作用 ,结果显示 :补肾益智方灌胃组大鼠脑内广泛区域的乙酰胆碱酯酶阳性神经纤维密度较模型对照组增加 (P <0 .0 5或P <0 .0 1) ,提示该方对AD模型脑内胆碱能神经元具有一定的保护作用。
|
| 关 键 词： | 阿尔茨海默病/中药疗法 补肾药/治疗应用 @补肾益智方/药理学 乙酰胆碱酯酶/药物作用 疾病模型 动物 大鼠 |
| 修稿时间： | 1999-06-16 |
Protective Effect of Bushen Yizhi Decoction on Brain Cholinergic System in Rat Model with Alzheimer's Disease |
| |
| HU Jingqing,LAI Shilong,WANG Qi,LIANG Weixiong,XIE Hong.Protective Effect of Bushen Yizhi Decoction on Brain Cholinergic System in Rat Model with Alzheimer's Disease[J].Journal of Guangzhou University of Traditional Chinese Medicine,1999,16(3):201-204. |
| |
| Authors: | HU Jingqing LAI Shilong WANG Qi LIANG Weixiong XIE Hong |
| |
| Abstract: | The protective effect of Bushen Yizhi Decoction(BYD)on brain cholinergic system in rat model with Alzheimer's disease(AD)was studied with histochemical technique to visualize acetylcholinesterase.AD rat model was established by intraperitoneral injection of D-galactose and ibotenic acid injection into bilateral Meynert nucles.The results showed that the density of acetylcholinesterase_containing fibers in extensive region of model rat brain treated with gastric perfusion of BYD was higher than that in model rat brain.This indicates BYD exerts a certain protective effect on brain cholinergic neuron in rat model with AD. |
| |
| Keywords: | ALZHIMER'S DISEASE/TCD therapy KIDNEY_REINFORCING DRUGS/ther use @BUSHEN YIZHI DECOCTION/pharmocology ACETYLCHOLINESTERASE/drug effects DISEASE MODELS ANIMAL RATS |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
