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高血压病中医证型与颈动脉内—中膜厚度及血浆Lp-PLA2表达的相关性研究
引用本文:黄妙芬,谢慧文.高血压病中医证型与颈动脉内—中膜厚度及血浆Lp-PLA2表达的相关性研究[J].广州中医药大学学报,2017,34(3).
作者姓名:黄妙芬  谢慧文
作者单位:1. 广州中医药大学,广东广州,510405;2. 广州中医药大学第一附属医院,广东广州,510405
摘    要:【目的】探讨高血压病中医证型与颈动脉内—中膜厚度(IMT)及人血浆脂蛋白磷脂酶A2(Lp-PLA2)表达水平之间的相关性,为中医临床早期防治高血压病及其并发症提供参考。【方法】收集55例肾精不足证、50例肝阳上亢证、65例痰湿中阻证高血压病患者(共170例),行颈动脉彩色多普勒超声观察颈动脉IMT,采用酶联免疫法检测血浆Lp-PLA2表达,比较和分析各组间IMT值、Lp-PLA2表达的差异。【结果】各证型之间颈动脉IMT值及Lp-PLA2表达水平差异有统计学意义(P0.01),痰湿中阻组颈动脉硬化比例及Lp-PLA2表达水平明显高于其他2组(P0.01)。【结论】从"痰"论治可能更有利于早期防治高血压病及其并发症。

关 键 词:高血压痛  中医证型  颈动脉硬化  脂蛋白磷脂酶A2

Correlation of Traditional Chinese Medicine Syndrome Types of Hypertension with Carotid Artery Intima-media Thickness and Plasma Lp-PLA2 Expression
HUANG Miao-Fen,XIE Hui-Wen.Correlation of Traditional Chinese Medicine Syndrome Types of Hypertension with Carotid Artery Intima-media Thickness and Plasma Lp-PLA2 Expression[J].Journal of Guangzhou University of Traditional Chinese Medicine,2017,34(3).
Authors:HUANG Miao-Fen  XIE Hui-Wen
Abstract:Objective To explore the correlation of traditional Chinese medicine (TCM) syndrome types of hypertension with carotid artery intima-media thickness (IMT) and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2),so as to provide a TCM therapy for early prevention and treatment of hypertension and its complications in clinic.Methods We collected a total of 170 cases of hypertension patients,55 with kidney-essence insufficiency syndrome,50 with ascendant hyperactivity of liver yang syndrome,and 65 with phlegm-damp retention in middle energizer syndrome.IMT was measured by the carotid Doppler ultrasound,and plasma Lp-PLA2 expression was examined by enzyme-linked immunosorbent assay.And then the differences of IMT and Lp-PLA2 expression among the three groups were compared and analyzed.Results There were significant differences of carotid artery IMT and Lp-PLA2 among the three groups(P< 0.01),and the number of patients with carotid atherosclerosis and the expression level of Lp-PLA2 in the group of phlegm-damp retention in middle energizer syndrome were higher than those intheothertwogroups(P<0.01).Conclusion Differentiation treatment based on phlegm may be more conducive to the prevention and treatment of hypertension and its complications.
Keywords:hypertension  traditional Chinese medicine(TCM) syndrome types  carotid artery atherosclerosis  lipoprotein-associated phospholipase A2 (Lp-PLA2)
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