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穴位埋线防治乳腺癌FEC化疗所致骨髓抑制的临床研究
引用本文:谢枫枫,陈凯霓,李宝,朱俊志.穴位埋线防治乳腺癌FEC化疗所致骨髓抑制的临床研究[J].广州中医药大学学报,2017,34(4).
作者姓名:谢枫枫  陈凯霓  李宝  朱俊志
作者单位:广州中医院大学第二附属医院, 广东省中医院, 广东广州 510120
基金项目:广东省中医药局科研课题
摘    要:【目的】比较穴位埋线加基础治疗与单纯基础治疗在防治乳腺癌FEC化疗所致骨髓抑制的疗效差异。【方法】将46例乳腺癌术后拟行第一周期FEC化疗的患者随机分为治疗组和对照组,每组23例。对照组给予中西医基础治疗(包括中药香砂六君子汤加减和胃止呕,归脾汤和龟鹿二仙汤加减养血生血,西药鲨肝醇和维生素B4),治疗组在对照组基础上增加穴位埋线治疗(取双侧足三里和肾俞穴),通过观察其骨髓抑制的情况来比较两组间的疗效差异。【结果】(1)化疗后第7天和第10天,治疗组的白细胞和中性粒细胞计数均高于对照组,差异均有统计学意义(P0.05或P0.01)。(2)在使用粒细胞集落刺激因子(G-CSF)方面,治疗组明显少于对照组,差异有统计学意义(P0.05)。(3)化疗后第10天,治疗组在改善骨髓抑制方面明显优于对照组,差异有统计学意义(P0.01)。【结论】穴位埋线加基础治疗预防FEC化疗后骨髓抑制的临床疗效较单纯基础治疗的疗效好,且安全性高。

关 键 词:乳腺癌  化疗  骨髓抑制  穴位埋线    足三里    肾俞  香砂六君子汤  龟鹿二仙汤  归脾汤

Clinical Study of Acupoint Catgut-embedding Therapy for Prevention and Treatment of Bone Marrow Depression in Breast Cancer Patients Induced by FEC Chemotherapy
XIE Feng-Feng,CHEN Kai-Ni,LI Bao,ZHU Jun-Zhi.Clinical Study of Acupoint Catgut-embedding Therapy for Prevention and Treatment of Bone Marrow Depression in Breast Cancer Patients Induced by FEC Chemotherapy[J].Journal of Guangzhou University of Traditional Chinese Medicine,2017,34(4).
Authors:XIE Feng-Feng  CHEN Kai-Ni  LI Bao  ZHU Jun-Zhi
Abstract:Objective To compare the clinical efficacy of acupoint catgut-embedding therapy plus fundamental treatment versus fundamental treatment alone for the prevention and treatment of bone marrow depression in breast cancer patients induced by FEC(fluorouracil, epirubicin and cyclophosphamide) chemotherapy. Methods A total of 46 post-operation breast cancer patients accepting the first cycle of FEC chemotherapy were randomly divided into treatment group and control group, 23 cases in each group. The control group was given fundamental treatment including oral use of Chinese medicine of modified Xiangsha Liujunzi Decoction for regulating stomach and arresting vomiting, modified Guipi Decoction and Gui Lu Erxian Decoction for nourishing blood and generating blood, and western medicine of Batilol Tablets and Vitamin B4 Tablets. The treatment group was given acupoint catgut-embedding therapy on bilateral Zusanli(ST36) and Shenshu(BL23) plus fundamental treatment. The effect on bone marrow depression in the two groups was observed after treatment. Results(1) On post-chemotherapy day 7 and 8, the count of white blood cells (WBC) and neutrophils (NE) in the treatment group was higher than that in the control group, the difference being significant(P < 0.05 or P < 0.01).(2) The utilization of granulocyte colony-stimulating factor(G-CSF) in the treatment group was less than that in the control group, the difference being significant (P < 0.05). (3) On post-chemotherapy day 10, the effect on improving bone marrow depression in the treatment group was superior to that in the control group, the difference being significant (P<0.01) . Conclusion The acupoint catgut-embedding therapy plus fundamental treatment is more effective and safe for the prevention and treatment of bone marrow depression in breast cancer patients induced by FEC chemotherapy than fundamental treatment alone.
Keywords:breast cancer  chemotherapy  bone marrow depression  acupoint catgut-embedding therapy  Zusanli (ST36)  Shenshu (BL23)  Xiangsha Liujunzi Decoction  Gui Lu Erxian Decoction  Guipi Decoction
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