慢性乙型肝炎患者血清免疫球蛋白的变化及临床意义

目的：探讨慢性乙型肝炎患者血清免疫球蛋白的变化及临床意义。方法：选取本院2011年2月-2012年10月收治的184例慢性乙型肝炎患者的临床资料，将所有患者分为慢性乙型肝炎组75例，慢性重型乙型肝炎组109例，并选取同时入院体检的80例健康体检者作为对照组，并对三组的免疫功能水平及患者的免疫功能水平变化情况与病情变化情况进行比较。结果：慢性乙型肝炎组和慢性重型乙型肝炎组的免疫球蛋白（IgG、IgA、IgM）均明显高于健康对照组，差异均有统计学意义（t=3.94、4.21、4.67；t=4.51、5.36、6.74， P〈0.05），且慢性重型乙型肝炎组的免疫球蛋白（IgG、IgA、IgM）水平均明显高于慢性乙型肝炎组，差异均有统计学意义（t=4.62、3.46、3.97， P〈0.05）。恶化组患者的PTA明显低于改善组，而免疫球蛋白（IgG、IgA、IgM）和TBIL均明显高于改善组，比较差异均有统计学意义（P〈0.05）。结论：慢性乙型肝炎患者的血清免疫蛋白水平及其相关指标水平可明显反应患者肝脏功能受损情况，对判断慢性乙型肝炎患者的病情及预后具有十分重要的临床意义。

Change Characteristics and Clinical Significance of Immune Globulin for Patients with Chronic Hepatitis B

Objective：To investigate the change characteristics and clinical significance of immune globulin for patients with chronic hepatitis B.Method：The clinical data of 184 chronic hepatitis B patients in our hospital from February 2011 to December 2012 were selected,and they were divided into chronic hepatitis B group for 75 cases and chronic severe hepatitis group for 109 cases.And selected 80 cases the same health examination people who admitted to hospital physical examination as the control group.The immunity level of three groups,changes of immune function level and condition on the immune function of patients were compared.Result：The chronic hepatitis B group and chronic severe hepatitis group in immunoglobulin （IgG、IgA、IgM）were significantly higher than the control group,the differences were statistically significant（t=3.94、4.21、4.67;t=4.51、5.36、6.74,P〈0.05）,and immunoglobulin（IgG、IgA、IgM）of chronic severe hepatitis group were significantly higher than chronic hepatitis B group, the differences were statistically significant（t=4.62、3.46、3.97,P〈0.05）.PTA of Worsening group was lower than the improvement group,and immunoglobulin（IgG、IgA、IgM）and TBIL were significantly higher than those in improvement group,the differences were statistically significant （P〈0.05）.Conclusion：Immune serum protein levels for patients with chronic hepatitis B can be significantly related reactions in patients with impaired liver function situation,which is the judgment in patients with chronic illness and prognosis with great clinical significance.