BNP及Copeptin水平与冠状动脉病变程度的相关性研究

目的:研究脑钠肽(BNP)及和肽素(Copeptin)水平与冠状动脉病变程度的相关性。方法:对本院收治的248例冠心病患者(分为AMI组、SAP组、UAP组)及100例非冠心病患者(对照组)进行BNP及Copeptin水平测定,并评估冠状动脉病变的程度,对各组结果进行比较分析。结果:AMI组、UAP组、SAP组的BNP、Copeptin水平及Gensini积分均显著高于对照组(P0.05),且AMI组、UAP组、SAP组之间比较差异也具有统计学意义(P0.05);左主干病变者的BNP及Copeptin水平显著高于其他病变支数者(P0.05),而3支病变者显著高于1支与2支病变者(P0.05),1支病变者与2支病变者差异则无统计学意义(P0.05)。结论:BNP及和肽素Copeptin水平与冠状动脉病变的程度及病变支数呈正相关,同时也能反映出心肌受损的程度。

Correlation Study of Brain Natriuretic Peptide （ BNP ） and Copeptin Level in Patients with Degree of Coronary Artery Lesions

Objective：To explore the clinical significance of detection of brain natriuretic peptide（BNP）and copeptin level in patients with coronary heart disease.Method：248 patients with coronary heart disease（group AMI,group SAP,and group UAP）and 100 non-coronary heart disease patients（control group）received detection of BNP and copeptin level,the extent of coronary artery disease were evaluated,the results were compared and analyzed.Result：BNP level,copeptin level and gensini score in group AMI,group SAP,and group UAP were higher than that in control group significantly（P〈0.05）,comparison of BNP level,copeptin level and gensini score in group AMI,group SAP,and group UAP also showed statistically significant（P〈0.05））. BNP and copeptin level in patients with left main coronary artery lesions were higher than other patients（P〈0.05）, level in patients with three lesions were higher than one and two lesions（P〈0.05）,patients with one and two lesions showed no significant（P〈0.05）. Conclusion：Level of BNP and copeptin is positively correlated with number of diseased lesions,and reflects the degree of myocardial damage to some extent.