本院肺炎克雷伯菌的临床分布及耐药性分析

目的：调查分析笔者所在医院2010—2012年肺炎克雷伯菌的临床分布及耐药情况，以指导临床合理使用抗菌药物。方法：采用回顾性方法收集笔者所在医院2010—2012年临床各类标本分离的肺炎克雷伯菌165株，对其药敏试验结果进行统计、分析。结果：肺炎克雷伯菌在病原菌中的检出率为2．14％，165株肺炎克雷伯菌对常用抗菌药物均产生不同的耐药性，这3年平均耐药率〉50％的有氨苄西林（94．2％）、头孢噻吩（69．1％），头孢呋辛（64．5％）和庆大霉素（52．7％）；耐药率较低的抗菌药物是环丙沙星（7．8％）、赈拉西林／他唑巴坦（8．3％）和阿卡米星（8．9％）等，对亚胺培南和美罗培南耐药率最低（O％）；肺炎克雷伯菌对头孢曲松、头孢吡肟和氨曲南耐药率呈现逐步上升趋势。结论：肺炎克雷伯菌的耐药性呈上升趋势，应加强抗菌药物管理，临床治疗应依照药敏试验结果选用抗菌药物。

Clinical Distribution and Resistance Analysis(Drug Resistance)of Klebsiell Pneumoniae in Our Hospital

Objective： To investigate and analyse the clinical distribution and the drug resistance of Klebsiella pneumoniae from 2010 to 2012 so as to guide reasonable use of antibiotics in clinical.Method： A total of 165 strains of Klebsiella pneumoniae isolates were collected from 2010 to 2012 retrospectively.Count and analyse the result of their drug sensitive tests.Result： The detection rate of Klebsiella pneumoniae is 2.14% in the pathogen. Different drug resistance to frequently-used antibiotics occurred among in the 165 strains.Drugs which the average resistance rate above 50% in the three years were ampicillin （ 94.2% ）, cephalothin （ 69.1% ）, cefuroxime （ 64.5% ）, gentamicin （ 52.7% ） .Drugs which the resistance rates were much lower were ciprofloxacin （ 7.8% ）, tazobactam sodiundpiperacillin sodium （ 8.3% ） and amikacin （ 8.9% ） .The resistance rates to impenem and meropenem were the lowest （ 0% ） ; the resistance of Klebsiella pheumoniae to Ceftfiaxone, cefepime and aztreonam were growing up gradually.Conclusion： The antimierobial resistance of Klebsiella pheumoniae has increased.The management of antibiotics should be strengthened and it＇ s important to choose appropriate antibiotics according to the results of drug sensitive tests.