阿尔茨海默症研究热点的战略情报分析

目的：对国家目前重点支持的重大慢性疾病阿尔茨海默症的研究进行战略情报分析，为阿尔茨海默症的医学专业研究及管理决策提供科学依据。方法：通过引文同被引聚类描述阿尔茨海默症领域研究的历史，借助战略坐标的思想绘制“引文战略坐标图”，从而进一步了解各研究热点的新颖度和关注度。通过主题词共词聚类发现阿尔茨海默症领域当前的研究热点，并在此基础上进行战略坐标分析，揭示各热点研究的发展阶段。结果：当前阿尔茨海默症领域相关研究的热点是阿尔茨海默症患者的物质代谢研究、阿尔茨海默症的病因及治疗方法等，其发展历程中利用特定临床特征来进行阿尔茨海默症的诊断、阿尔茨海默症的淀粉样蛋白级联假说研究等得到了较大关注。结论：综合利用引文战略坐标和共词战略坐标可分析出阿尔茨海默症研究领域的热点及发展历史。

Strategic information analysis of hotspots in studies on Alzheimer's disease

Objective To provide the scientific evidence for studying Alzheimer''s disease (AD) and decision-making for its management by analyzing the strategic information of hotspots in studies on AD. Methods "Citation strategic coordinate diagram" was plotted by describing the history of studies on AD with co-citation clustering for further understanding the novelty and concern of hotspots in studies on AD. The current hotspots in studies on AD were discovered by co-words clustering and their strategic coordinates were analyzed to reveal their development periods.Results The current hotspots in studies on AD were substance metabolism in AD patients, etiology of AD and therapies for AD. The diagnosis of AD according to its clinical characteristics and hypothesis on amyloid cascade in AD patients were greatly concerned.Conclusion Citation strategic coordinate analysis and co-words strategic coordinate analysis can display the hotspots in studies on AD and their development history.