阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病相关性的Meta分析

目的 运用Meta分析研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与胃食管反流病(GERD)之间的相关性。方法 使用计算机对Pubmed、Embase、CNKI、万方及维普数据库进行关键词检索,文献的检索起至时间从建库起到2020年5月为止,将关于OSAHS与GERD相关性的病例对照研究进行收集纳入,排除非公开发表及非病例对照研究,最终按纳入和排除标准筛选文献并评价其质量。利用RevMan 5.3软件对研究数据进行Meta分析,根据异质性检验结果选择合适的效应模型进行统计,并合并效应量OR值。结果 最终纳入病例对照研究共计18个,Meta分析结果如下：对于睡眠呼吸暂停低通气指数(AHI),P＜0.05,差异具有统计学意义；对于GERD症状积分,P＜0.05,差异具有统计学意义；对于体重指数(BMI),P＜0.05,差异具有统计学意义。结论 在部分方面,阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病之间存在密切关系。由于纳入的研究存在一定程度的异质性,故仍需更多大样本的RCT研究证明本Meta分析的结论。

Relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: A Meta-analysis

Objective To evaluate the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and gastroesophageal reflux disease (GERD) using a meta-analysis method. Methods Pubmed, Embase, CNKI, Wanfang and Weipu databases were retrieved by computer from the date of literature retrieval to May 2020. All published case-control studies on the correlation between OSAHS and GERD were collected. Literatures were screened according to inclusion and exclusion criteria and the quality of included studies was evaluated. RevMan was used.5.3 The software carries out meta-analysis, selects the model according to the test results of heterogeneity and merges the OR values of effect quantities, and carries out publication bias and sensitivity analysis at the same time. Result A total of 18 case-control studies were included, and the results of meta-analysis showed that in terms of sleep apnea hypopnea index (AHI), P<0.05, the difference between the two groups was statistically significant; in terms of GERD symptom score, P<0.05, the difference between the two groups was statistically significant; in terms of body mass index (BMI), P<0.05, the difference between the two groups was statistically significant in each study. Conclusion In part, there is a close relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease. Considering the heterogeneity among studies, better RCT studies need to be designed to further prove the conclusions of this meta-analysis.