血液净化联合季德胜蛇药片救治蛇咬伤致急性肾损伤临床观察刘皖娟 叶慧娟 叶文燕 丽水市中心医院急诊科 323000

目的 探讨血液净化联合季德胜蛇药片救治蛇咬伤致急性肾损伤的临床疗效。方法 选择2010年1月至2015年1月于我院接诊69例毒蛇咬伤后急性肾损伤患者,用随机数字表分组分为观察组和对照组,对照组33例主要运用常规的抗蛇毒血清进行治疗,观察组36例在对照组治疗基础上加用血液净化联合季德胜蛇药片,治疗后对比两组疗效及肾功能Cr,BUN,Cys-C,β2-MG,KIM-1,NAG指标情况。结果 治疗后对比两组有效率,观察组有效率94.44%,对照组有效率75.76%,观察组有效率高于对照组,统计对比两组数据,P<0.05；对比两组肾功能指标情况,观察组各项指标较对照组改善更为明显,统计对比差异性显著,P<0.05。结论 血液净化联合季德胜蛇药片在治疗蛇咬伤致急性肾损伤中疗效确切,,可以提高患者的治愈率,及时有效的改善肾功能,值得临床推广应用。

Clinical observation of blood purification combined with Jidesheng antivenornous Tablets for snakebite induced acute kidney injury

Objective To investigate the clinical curative effect of blood purification combined with Jidesheng antivenornous Tablets for snakebite induced acute kidney injury. Methods 69 cases snakebite acute kidney injury patients were divided into observation group and control group by random digits grouped table from January 2010 to January 2015 in our hospital admissions.33 cases were treated with conventional anti venom serum in the control group, the observation group of 36 cases in the control group wre treated with blood purification combined with Jidesheng antivenornous Tablets based with the control group,the efficacy and renal function of the two groups were compared with Cr, BUN, Cys-C, 2-MG, KIM-1, NAG after treatment. Results the effective rate of the observation group was 94.44%,and 75.76% in the control group after treatment,the observation group was higher than the control group,the statistical was significant differences between the two groups,P<0.05;the observation group of indicators improved more compared with the control group compared with the two groups of renal function indicators,and the statistical differences were significant, P<0.05. Conclusion Blood purification combined with Jidesheng snake Tablets in curative effect, could improve the patient cure rate, and effectivly to improve renal function timely in treating snake bite induced acute renal injury ,was worthy of clinical application.