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刺五加注射液对肺肿瘤化疗患者免疫调节作用的研究
引用本文:王峻,何嘉言,孙宏高.刺五加注射液对肺肿瘤化疗患者免疫调节作用的研究[J].浙江中西医结合杂志,2001,11(6):339-340,351.
作者姓名:王峻  何嘉言  孙宏高
作者单位:杭州市红会医院杭州 310003
摘    要:目的:研究刺五加辅助化疗对肿瘤患者的免疫调节作用,以寻找肿瘤治疗新途径。方法:以FACS、ELISA双抗体夹心法及LDH稀放法分别检测淋巴细胞的表面标志、血清细胞因子、sIL-2R的分泌水平及外周血淋巴细胞(PBL)的抗肿瘤活性。结果:应用刺五加辅助治疗后,患者PBL的CD3、CD4分子表达升高;Th1型细胞因子分泌增加,sIL-2R下降;淋巴细胞的抗肿瘤活性(NK和LAK活性)均显著增强。结论:刺五加可改善肺肿瘤化疗患者的免疫状况,提高机体的抗肿瘤效应,在临床抗肿瘤辅助治疗中具有广阔的应用前景。

关 键 词:肺肿瘤  刺五加  免疫调节  中医药疗法

Studies on the Immune Regulation Effects of Ci-Wu-Jia Injectio n in Assisted Chemotherapy for Pulmonary Cancer Cases
Wang Jun,He J iayan,Sun Honggao.Studies on the Immune Regulation Effects of Ci-Wu-Jia Injectio n in Assisted Chemotherapy for Pulmonary Cancer Cases[J].Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2001,11(6):339-340,351.
Authors:Wang Jun  He J iayan  Sun Honggao
Institution:Wang Jun,He Jiayan,Sun Honggao.Red Cross Hospital of Hangzhou,Hangzhou 310003
Abstract:Objective:To explore the immune regulation of Ci Wu Jia injection in treating pulmonary cancer so as to find a new therapy for the cancer treatment.Methods:Detections were made on the surface markers of the lymphocytes,cytokine,sil 2R secretion and peripheral lymphocytes activities by using ELISA,FACS and LDH releasing methods. Results: After the Ci Wu Jia assisted therapy,the CD 3 and CD 4 were raised with increased Th1 secretion and lowered sil 2R level.NK and LAK were enhanced in their functions.Conclusions:Ci Wu Jia injection could improve the immune function against the cancer cells with a great prospect in the treatment of cancers.
Keywords:Ci  Wu  Jia injection  Lung tumor  Immune regulation
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