未破裂卵泡黄素化综合征中医证型与证素分布特点的文献研究

未破裂卵泡黄素化综合征(luteinized unruptured follicle syndrome,LUFS)指卵泡成熟后不破裂排出卵子,而发生原位黄素化并分泌孕激素,使机体发生与排卵周期类似的变化,是导致排卵障碍性不孕的一个重要原因1]。随着超声卵泡监测技术与促排药物的广泛运用,LUFS的检出率和发病率呈增高趋势,在不孕症患者中达25%~45%2]。

Distribution Characteristic of Traditional Chinese Medicine Syndromes and Syndrome Elements of Luteinized Unruptured Follicle Syndrome: A Literature Research

Objective: To explore the distribution characteristic of Traditional Chinese Medicine (TCM) syndromes and syndrome elements of luteinized unruptured follicle syndrome (LUFS) based on literatures. Methods: Literatures containing TCM syndromes and syndrome elements of LUFS were retrieved from Wangfang Data, CNKI and VIP from the beginning of establishment of library to December 2020. Then the names of TCM syndromes and syndrome elements were extracted and frequency statistics, cluster analysis were conducted. Results: Totally 83 articles were included, involving 26 syndrome names. The common syndromes were kidney deficiency-blood stasis syndrome, liver-qi stagnation syndrome, kidney deficiency-liver stagnation syndrome, blood stasis syndrome, kidney deficiency syndrome and phlegm-dampness syndrome. There were 5 location syndrome elements and 11 nature syndrome elements. The common location syndrome elements were uterus, kidney, liver and the common nature syndrome elements were essence deficiency, blood stasis, qi stagnation, yang deficiency, dampness, yin deficiency. The common syndrome element combination was four syndrome element combination, among which the combination of kidney, uterus, essence deficiency and blood stasis occurred most frequently. There were 6 types of syndrome elements by cluster analysis: (1) liver, qi stagnation; (2) phlegm, dampness; (3) spleen, yang deficiency; (4) yin deficiency; (5) uterus, blood stasis; (6) kidney, essence deficiency. Conclusion: The characteristic of TCM syndromes and syndrome elements of LUFS is combination of deficiency and excess. Deficiency syndromes are mainly deficiency of essence, yin and yang in kidney while excess syndromes are mainly blood stasis, qi stagnation, phlegm-dampness. The key points of syndrome differentiation can be summarized as deficiency, blood stasis, deficiency and phlegm-dampness.