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Epi-LASIK与PRK术后兔角膜组织病理学观察
引用本文:张元钧,陆勤康,王慧云,陈辉.Epi-LASIK与PRK术后兔角膜组织病理学观察[J].浙江中西医结合杂志,2011,21(9):613-615.
作者姓名:张元钧  陆勤康  王慧云  陈辉
作者单位:1. 浙江省宁波市鄞州人民医院眼科,宁波,315040
2. 南通大学附属医院
基金项目:浙江省宁波市医疗卫生科技专项
摘    要:目的:通过比较准分子激光角膜表层切削术(Epi-LASIK)及PRK术后角膜上皮及基质的愈合过程,探讨Epi-LASIK术后上皮瓣对角膜创后修复的影响。方法:中华大耳白兔33只,随机分为观察组30只,正常对照组3只。观察组兔随机一眼行Epi-LASIK,另一眼行PRK,术后1、7天,1、3、6个月观察上皮下雾状混浊(Haze)情况;于各时相点处死动物取角膜并行HE染色,通过角膜组织病理学观察比较角膜上皮及基质愈合情况。正常对照兔不作手术。结果:术后Epi-LASIK组上皮愈合过程较PRK组缓慢(P〈0.05),Epi-LASIK组Haze程度较PRK组轻;角膜组织病理学显示,Epi-LASIK组术后3~6个月时角膜上皮厚度及角膜前基质细胞数明显低于PRK组(P〈0.05)。结论:Epi-LASIK上皮瓣在术后角膜创面的愈合中有重要作用。

关 键 词:EPI-LASIK  PRK  准分子激光  角膜  表面切削  上皮下混浊

Histopathologic Observation On Wound Healing in Rabbit Cornea after Epi-LASIK and PRK
ZHANG Yuanjun,LU Qinkang,WANG Huiyun,CHEN Hui.Histopathologic Observation On Wound Healing in Rabbit Cornea after Epi-LASIK and PRK[J].Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2011,21(9):613-615.
Authors:ZHANG Yuanjun  LU Qinkang  WANG Huiyun  CHEN Hui
Institution:ZHANG Yuanjun,LU Qinkang,CHEN Hui,et al.Yinzhou People's Hospital,Ningbo(315040),Chin
Abstract:Objective:To investigate the effect of corneal flap on corneal wound healing after laser-assisted surface keratectomy.Methods:A total of 30 Chinese rabbits(66 eyes) were randomly received Epi-Lasik in one eye and PRK in the other eye.Other 3 rabbits(6 eyes) served as normal controls.Haze was evaluated at different postoperative time points(1 d,7 d,1 month,3 months,and 6 months).Six rabbits were sacrificed at each time point and the healing process of corneal epithelium and stoma were evaluated by HE stainin...
Keywords:EPI-LASIK PRK excimer laser cornea surface keratectomy Haze  
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