顺应月经周期的中药及针刺疗法治疗排卵障碍性不孕症的疗效观察

不孕症是指一年以上未采取任何避孕措施、性生活正常,但是未能成功妊娠者。临床上,将不孕症分为原发性不孕与继发性不孕两种,常见病因有排卵障碍、精液异常、输卵管异常及子宫内膜异位症等,影响患者健康生活1]。排卵障碍属于生殖内分泌系统常见病,亦是引起女性不孕的重要原因。数据调查结果表明:不孕症患者中排卵障碍引起的不孕占25.0%~30.0%2]。克罗米芬、促性腺激素及人绒毛膜促性腺激素等均为排卵障碍性不孕症患者常用的治疗药物,虽然能改善患者症状,但是远期预后较差,排卵率及妊娠率较低3]。

Observation on the curative effect of traditional Chinese medicine and acupuncture in the treatment of ovulatory infertility

Objective: To observe the curative effect of traditional Chinese medicine and acupuncture in the treatment of ovulatory infertility. Methods: 134 patients with ovulatory dysfunction infertility (kidney deficiency and blood stasis type) from January 2017 to June 2018 were randomly divided into two groups, 67 cases in each group. The control group was treated with western medicine intervention, and the observation group was treated with traditional Chinese medicine cycle therapy combined with acupuncture on the basis of the control group. After 6 menstrual cycles, the effect of the patients was evaluated. After the treatment, the patients were followed up for 2 years. The syndrome score, sex hormone level, mature follicle diameter, endometrial thickness, endometrial receptivity, adverse reactions, ovulation rate and pregnancy rate of the two groups were compared. Results: two weeks after treatment, the scores of infertility, dysmenorrhea, abnormal menstrual color, low back acid and dizziness with tinnitus in the observation group were lower than those in the control group (P < 0.05); the levels of sex hormone P, E2 and FSH in the observation group were higher than those in the control group (P < 0.05); the level of LH in the observation group was lower than that in the control group (P < 0.05); the diameter and intimal thickness of mature follicles in the observation group were larger than those in the control group (P < 0.05); the PI in the observation group was higher than that in the control group (P < 0.05) The incidence of nausea and vomiting, diarrhea and constipation, rash and abnormal liver and kidney in the two groups had no statistical significance (P > 0.05); the pregnancy rate and ovulation rate in the observation group were higher than those in the control group (P < 0.05). Conclusion: Traditional Chinese medicine cycle therapy combined with acupuncture is helpful to reduce syndrome score, improve sex hormone level, increase follicle diameter and endometrial thickness, reduce endometrial receptivity, without increasing the incidence of adverse reactions, and obtain higher ovulation rate and pregnancy rate, which is worthy of popularization and application.