长链非编码RNA在类风湿关节炎中的作用及中药有效成分干预研究进展

类风湿关节炎(rheumatoid arthritis,RA)是以持续性滑膜炎为主要特征的慢性、全身性自身免疫疾病,可造成肌腱、韧带和软骨的损伤,最终导致关节畸形和功能障碍,严重影响患者的生活质量,给社会经济造成巨大负担。RA全球发病率达0.5%~1%1],但发病机制仍不明确。研究表明,50%RA发病与基因相关2]。

Research Progress of Role of Long noncoding RNA in Rheumatoid Arthritis and Chinese Medicine Intervention

Rheumatoid arthritis is a refractory and chronic inflammatory autoimmune disease. In recent years, the research on the pathogenesis of rheumatoid arthritis has gone deep into the genetic and molecular level, and certain progress has been made. Among them, long noncoding RNA is a type of RNA molecule that is longer than 20 nucleotides and does not have the function of encoding a protein. It can participate in immune and inflammatory responses through a variety of ways. It plays an important role in the process of gene expression, cell differentiation, proliferation and invasion. This article summarizes the research progress of the molecular mechanism of lncRNA in rheumatoid arthritis and elaborates the intervention mechanism of traditional Chinese medicine to provide new research directions for the prevention and treatment of rheumatoid arthritis by traditional Chinese medicine.