PTEN基因多态性与抑郁症风险的相关性研究

正抑郁症患者的临床特征主要包括持续缓慢的思维、抑郁情绪以及认知障碍,对日常生活活动的兴趣下降~(1])。抑郁症的发病机制复杂,与多种因素有关,如年龄、性别、婚姻状况、种族、教育、环境和遗传因素等,其中遗传因素是目前研究者们关注的热点之一。PTEN基因(gene of phosphate and tension homology deleted on chrom-some ten,PTEN)是一种肿瘤抑制

Correlation between the PTEN gene polymorphism and risk of depression.

Objective To study the correlation between PTEN gene polymorphism of rs2735343, rs112025902 and rs701848 locus and the risk of depression. Methods A total of 240 patients with depression from May 2013 to August 2016 were selected as the study group, and another 240-healthy people were recruited as the control group. 5 ml of fasting elbow vein blood of all subjects were taken and genomic DNA (gDNA) extracted. After PCR amplification and direct sequencing, the correlation between PTEN gene polymorphism of rs2735343, rs112025902 and rs701848 locus and the risk of depression were analyzed. Results There was significant difference between rs2735343 locus, rs112025902 locus and rs701848 locus genotype and allele frequency in the study group and control group (P <0.05). The GC + CC genotype of the rs2735343 locus of the PTEN gene was associated with an increased risk of depression (P = 0.000, OR = 2.710, 95% CI = 1.731-4.253), and the C allele of the rs2735343 locus was associated with an increased risk of depression (P = 0.006, OR = 1.437, 95% CI = 1.097-1.884). AT + TT genotype of rs112025902 locus was associated with an increased risk of depression (P = 0.000, OR = 2.918, 95% CI = 1.885-4.528), and the T allele of the rs112025902 locus was associated with an increased risk of depression (P = 0.000, OR = 2.862, 95% CI = 2.183-3.754). The TC+CC genotype of rs701848 locus was associated with an increased risk of depression (P = 0.000, OR = 4.498, 95% CI = 2.866-7.079), and the C allele of rs701848 locus was associated with an increased risk of depression (P = 0.000, OR = 3.862, 95% CI = 2.928-5.096). The scores of the HAMD score and factors associated with depression scores of the rs2735343 locus C allele (GG + CC) carriers in the depressive patients were significantly lower than in the GG genotype carriers (t = 11.837, 5.191; P = 0.000, 0.000). The HAMD total score and anxiety factor score of rs112025902 locus T allele (AT + TT) carriers were significantly higher than AA genotype carriers, the HAMD total score and anxiety factor scores of rs701848 locus C allele carriers (TC + ??CC) were significantly higher than TT genotype carriers, the differences were statistically significant (t = 7.362, 5.640; P = 0.000, 0.000/t = 8.010, 6.051; P = 0.000, 0.000). Conclusion The rs2735343, rs112025902 and rs701848 polymorphisms of the PTEN gene may be associated with the risk of depression and depressive symptoms.