郁金抗抑郁作用的实验研究

目的观察郁金对小鼠抑郁的影响。方法采用小鼠强迫游泳实验、悬尾实验和拮抗利血平所致的抑郁症状实验。结果郁金高、中、低剂量组均可缩短小鼠强迫游泳、悬尾不动时间和拮抗利血平所致小鼠体温下降作用(P<0.01,P<0.05),郁金高、中剂量组可拮抗利血平所致小鼠运动不能作用(P<0.01),郁金高剂量组拮抗利血平所致小鼠眼睑下垂作用(P<0.05)。结论郁金对小鼠抑郁症的强迫游泳模型、悬尾模型和拮抗利血平所致的抑郁症模型均有治疗作用,且该作用与药物的剂量密切相关。

An Experimental Study on the Antidepressant of Yujin in Mice

Objective To observe the effects of Yujin on depressive mouses.Methods The following meth- ods have been carried out:the mouse forced-swimming test,tail suspension test and anti-reserpine symptom test.Results The immobility time of the forced swimming,tail suspension test and the temperature decrease of anti-reserpine test were significantly shortned in the Yujin high,middle and low dose groups(P<0.01,P<0.05,respectively).The immobility action of the mouses of the anti-reserpine test could be inhibited in the Yu- jin middle and high dose groups(P<0.01).The ptosis effect of the anti-reserpine test could be inhibited in the Yujin high dose group(P<0.05).Conclusion Yujin plays an obvious role to cure the forced-swimming depression model,tail suspension depresssion model and anti-reserpine model of the mouses' depression.It sug- gested that the antidepressant effect of Yujin depend on the dose of drug.