枸杞籽油对2型糖尿病C57BL/6J小鼠血清SOD、MDA及GSH的影响

目的研究枸杞籽油对2型糖尿病C57BL/6小鼠血清中超氧化物歧化酶（SOD）、丙二醛（MDA）及还原型谷胱甘肽（GSH）的影响。方法将实验动物随机分为正常对照组、糖尿病模型组、枸杞籽油0.025、0.05、0.1 mL/10g剂量干预组5组,除正常对照组外,其余以高脂饲料饲喂4周后的雌雄各半C57BL/6小鼠腹腔注射链尿左菌素（STZ,125mg.kg-1）,诱导2型糖尿病模型。检测各组血糖水平及血清SOD、MDA及GSH的变化。结果枸杞籽油各组与糖尿病模型组相比较,SOD都有所升高（P〈0.05）;枸杞籽油中剂量干预组GSH明显升高（P〈0.05）;MDA明显下降（P〈0.05）。结论枸杞籽油能改善2型糖尿病C57BL/6小鼠的抗氧化能力并有助于降低其血糖水平。

Effect of Lycium Barbarum Seed Oil on Serum SOD,MDA and GSH in C57BL/6J Mice with Type-2 Diabetes

Objective To explore the effect of Lycium Barbarum seed oil on serum superoxide desmutase（SOD）,malondealdehycle（MDA） and reduced glutathione hormone（GSH） in C57BL/6J mice with type-2 diabetes.Methods C57BL/6J mice at 6-week age were fed with hige-fat diet for 4 weeks and then received intraperitoneal injection of STZ（dose：125mg·kg-1） to induce type-2 diabetes.These mice were divided randomly into the diabetic control group,0.025mL/10g、0.05mL/10g、0.1mL/10g Lycium seed oil group.10 mice fed on usual diet were set as normal controls.Blood sugar were detected at 4th and 5 week,and changes in SOD,MDA and GSH were detected at week 10th week.Results Compared with diabetes control group,the level of SOD and GSH increased significantly in 0.05 mL/10g lyceum seed oil group（P0.05） and the level of MDA decreased significantly（P0.05） in 0.05 mL/10g lyceum seed oil group.Conclusion Sub-high dose of Lycium seed oil maybe effective to improve the antioxidative capability in C57BL/6J mice with type-2 diabetes.