| 氧化苦参碱对青霉素致痫大鼠学习记忆及海马P-JNK表达的影晌 |
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| 引用本文： | 杨文谦,刘红梅,赵衍,陈晓霞,张荣华,白洁.氧化苦参碱对青霉素致痫大鼠学习记忆及海马P-JNK表达的影晌[J].宁夏医科大学学报,2011(5):418-420,F0003. |
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| 作者姓名： | 杨文谦 刘红梅 赵衍 陈晓霞 张荣华 白洁 |
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| 作者单位： | 宁夏医科大学;宁夏医科大学基础医学院实验教学示范中心;宁夏医科大学基础医学院生理学系; |
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| 基金项目： | 宁夏自然科学项目(NZ0784); 宁夏回族自治区教育厅高等学校科研项目(2006237号) |
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| 摘 要： | 摘要：目的观察氧化苦参碱（Oxymatrine，OXY）对青霉素（Penicillin，PEN）致痫大鼠学习记忆和海马神经元P-JNK表达的影响。方法成年SD大鼠24只随机分为生理盐水对照组（Normalsaline，NS）、癫痫模型组（Epilepsy，EP）、OXY组和JNK抑制剂组（SP600125，SP），腹腔注射青霉素诱导大鼠癜痫发作，观察大鼠行为学改变，Morris水迷宫检测大鼠空间学习和记忆，免疫组化测定海马组织内P-JNK阳性细胞数。结果与EP组对比，OXY组大鼠逃避潜伏期和穿越平台次数明显减少（P〈0．05）；海马组织内P-JNK阳性细胞数明显降低（P〈0．05）。结论OXY可能通过抑制JNK信号通路的活化发挥对癫痫大鼠在空间学习和记忆方面的保护作用。
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| 关 键 词： | 氧化苦参碱 癫痫 P-JNK 空间学习记忆 |
Effect of Oxymatrine on Learning and Memory of Epileptic Rats and the Expression of p-JNK in Hippocampus |
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| YANG Wen-qian,LIU Hong-mei,ZHAO Yan,CHEN Xiao-xia,ZHANG Rong-hua,BAI Jie.Effect of Oxymatrine on Learning and Memory of Epileptic Rats and the Expression of p-JNK in Hippocampus[J].Journal of Ningxia Medical College,2011(5):418-420,F0003. |
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| Authors: | YANG Wen-qian LIU Hong-mei ZHAO Yan CHEN Xiao-xia ZHANG Rong-hua BAI Jie |
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| Institution: | YANG Wen-qian,LIU Hong-mei,ZHAO Yan,CHEN Xiao-xia,ZHANG Rong-hua,BAI Jie(Department of Physiology,Ningxia Medical University,Yinchuan 750004) |
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| Abstract: | Objective To observe the effect of oxymatrine on the expression of p-JNK in hippocampus and the spatial learning and memory of penicillin-induced epileptic rats,as well as to investigate its mechanisms.Methods 24 SD rats were randomly divided into four groups,which were normal saline control group(NS),epilepsy group(EP),Oxymatraine group(OXY)and JNK inhibitor group(SP600125,SP).Penicillin was intraperitoneally injected in rats to establish epileptic animal model.Behavioral changes were observed and immunohi... |
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| Keywords: | OXY epilepsy p-JNK spatial learning and memory |
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