辛开苦降法合“标准三联”治疗幽门螺杆菌阳性慢性非萎缩性胃炎临床研究

目的研究辛开苦降法合西药"标准三联"治疗幽门螺杆菌(Helicobacter pylori,Hp)阳性的慢性非萎缩性胃炎的临床疗效。方法将84例Hp阳性的慢性非萎缩性胃炎患者随机分为两组,治疗组42例应用加味半夏泻心汤合抗Hp的西药"标准三联"治疗;对照组42例单纯应用"标准三联"治疗。两组均分别治疗14 d,停药30 d后,复查Hp并判断治疗前后临床症状积分的改变情况。结果对照组治疗后Hp根除率为76.2%,治疗组为92.2%,两组比较差异有统计学意义(P0.05)。对于整体积分疗效中,对照组总有效率为81.0%,治疗组为95.2%,两组比较差异有统计学意义(P0.05)。结论辛开苦降法合"标准三联"治疗Hp阳性的慢性非萎缩性胃炎,比单纯应用西药,可更好的根除Hp和改善临床症状。

Clinical Study of Helicobacter Pylori Positive Chronic Non - Atrophic Gas- tritis Treated with Xinkaikujiang Method and Standard Triple Therapy

Objective To study the clinical efficacy of Helicobacter pylori （Hp） positive chronic non - atrophic gastritis treated with Xinkaikujiang method and the standard triple therapy of western medicine. Methods Eighty - four cases of Hp positive chronic non - atrophic gastritis were randomized into two groups. In the treatment group ,42 cases were treated with modified Banxia Xiexin Decoction and the anti - Hp western medicinal triple therapy. In the control group,42 cases, the standard triple therapy was just ap- plied. The treatment lasted for 14 days in the two groups. In 30 days of medication discontinuity, Hp was re - examined and the changes in clinical symptoms scores were judged. Results Hp elimination rate was 76.2% after treatment in the control group and was 92.2% in the treatment group, indicating the significant difference （ P 〈 0.05 ）. Concerning to the overall efficacy score, the total effective rate was 81.0% in the con- trol group and was 95.2% in the treatment group, indicating the significant difference （ P 〈 0. 05 ）. Conclu- sion Xinkaikujiang method combined with the standard triple therapy of western medicine is much more ef- fective in removing Hp and relieving clinical symptoms as compared with the simple application of western medicine in the treatment of Hp positive chronic non - atrophic gastritis.