中医治疗方案在肝癌患者术后应用的初步分析

目的对中医治疗方案在肝癌患者术后的效果进行初步分析。方法选择在长海医院和东方肝胆医院进行手术切除术后的肝癌患者,按患者的术后治疗情况分为西医治疗组和华蟾素治疗组。按患者的术中所见和影像检查进行分期,通过随访调查患者的复发情况和生存情况,分析患者乙型肝炎合并情况,AFP水平、肝癌TNM分期等,并了解患者不同因素下的复发情况。结果Ⅰa～Ⅱb期肝癌患者的生存分析提示华蟾素治疗组患者较西医治疗组长,各个肿瘤分期的中位无瘤生存时间分别为18.43、11.97、11.53、5.7个月和14.81、7.73、6.00、4.53个月。AFP mRNA阴性患者1、2、3年生存率及无瘤生存率均比AFP mRNA阳性患者高（P〈0.05）。华蟾素治疗组AFP阳性各水平的患者中位无瘤生存时间分别为13.00、11.97和11.93个月,西医治疗组患者中位无瘤生存时间分别为8.10、7.1和5.83个月。结论华蟾素用于治疗原发性肝癌术后复发可能有效,但因为回顾性研究,其结果有待进一步证实。

Preliminary Analysis on Chinese Medicine Therapeutic Program for the Liver Cancer Patients after Operation

Objective To primarily analyze the efficacy of Chinese medicine therapeutic program for the liver cancer patients after operation.Methods The liver cancer patients after resection were selected from Changhai Hospital and Dongfang Liver and Gallbladder Hospital.According to the post-operative treatment situations,the patients were divided into a western medicine group and a cinobufotalin group.The cases were staged in light of the findings in operation and image examination.The recurrence and survival situation were investigated in follow-up visit.The complication of hepatitis B,AFP level,liver cancer TNM staging and the others were analyzed.Additionally,the different factors of recurrence were analyzed for the patients.Results The survival analysis for the liver cancer patients at Ia-IIb stages suggested that the life span for the patients in the cinobufotalin group was longer than that in the western medicine group,in which the disease-free median life span was 18.43,11.97,11.53 and 5.7 months in the cinobufotalin group,and was 14.81,7.73,6.00 and 4.53 months in the western medicine group separately in each cancer stage.The life span of 1,2 and 3 years for the patients with AFP mRNA negative as well as the disease-free median life span were higher than those for the patients with AFP mRNA positive(P<0.05).In the cinobufotalin group,the disease-free media life span was 13.00,11.97 and 11.93 months separately for the patients with AFP positive of different levels.In the western medicine group,that was 8.10,71 and 5.83 months separately.Conclusion Cinobufotalin is probably effective in the treatment of the recurrence of primary liver cancer after the operation.But,a further verification is required as for this conclusion is based on the retrospective study.